Description

3-Cyclopropyl-1-(2-Fluoro-4-Iodophenyl)-6-(Methylamino)Pyrimidine-2,4(1H,3H)-Dione is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure featuring cyclopropyl, fluoro, and iodo substituents. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly due to its potential as a key building block in kinase inhibitor synthesis. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of targeted small molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially in oncology and antiviral research.
• Kinase Inhibitor Development: Used as a core scaffold or building block for the research and synthesis of novel protein kinase inhibitors.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties of lead compounds.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs) for clinical trials.
• Biochemical Tool Compound: May be utilized in biochemical assays to study specific enzyme interactions and pathways.
• Academic Research: Used in university and institutional laboratories for fundamental research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	3-Cyclopropyl-1-(2-Fluoro-4-Iodophenyl)-6-(Methylamino)Pyrimidine-2,4(1H,3H)-Dione
CAS No.	871700-22-0
Molecular Formula	C14H13FIN3O2
Molecular Weight	401.18 g/mol
Synonyms	6-(Methylamino)-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)pyrimidine-2,4(1H,3H)-dione; 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)-1,2,3,4-tetrahydropyrimidine-2,4-dione; 871700-22-0; 1-(2-Fluoro-4-iodophenyl)-6-(methylamino)-3-cyclopropylpyrimidine-2,4(1H,3H)-dione; 6-(Methylamino)-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our production of 3-Cyclopropyl-1-(2-Fluoro-4-Iodophenyl)-6-(Methylamino)Pyrimidine-2,4(1H,3H)-Dione adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment. We support development projects with the option for customized purity grades and analytical method development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.