Description

5-Pyrimidinecarboxylic Acid, 4-Amino-6-[1-[(1R)-2-Cyano-1-Cyclopentylethyl]-1H-Pyrazol-4-Yl]- is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound matters because it provides a critical, structurally defined building block essential for research and development in modern drug discovery programs, particularly those targeting specific biological pathways. Pharmaceutical R&D teams and fine chemical manufacturers need this material to ensure precise molecular construction, batch-to-batch consistency, and to accelerate the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel small-molecule drug candidates.
• API Synthesis: Used as a critical building block in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization in drug discovery pipelines.
• Process Chemistry Development: Serves as a reference standard and starting material for scaling up synthetic routes under GMP or non-GMP conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Biochemical Research: Potential use as a tool compound or inhibitor in biochemical assays to study specific enzyme or receptor interactions.

Basic Information

Item	Detail
Product Name	5-Pyrimidinecarboxylic Acid, 4-Amino-6-[1-[(1R)-2-Cyano-1-Cyclopentyl]ethyl]-1H-Pyrazol-4-Yl]-
CAS No.	2606144-44-7
Molecular Formula	C16H18N6O2
Molecular Weight	326.36 g/mol
Synonyms	4-Amino-6-[1-[(1R)-2-cyano-1-cyclopentylethyl]-1H-pyrazol-4-yl]pyrimidine-5-carboxylic acid; (R)-4-Amino-6-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)pyrimidine-5-carboxylic acid; 4-Amino-6-(1-((R)-2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)pyrimidine-5-carboxylic acid; CAS 2606144-44-7; Advanced Pyrimidine-Pyrazole Intermediate; Chiral Cyclopentyl Nitrile Derivative
EINECS	Contact for details

Quality Control

Our 5-Pyrimidinecarboxylic Acid derivative is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.