Description

(2S,3S,5R)-N-(4-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)BUTYL)-3-HYDROXY-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-CARBOXAMIDE is a sophisticated, multi-functional nucleoside analog derivative designed for advanced research and development. This compound is engineered as a critical building block for the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers requiring high-purity, structurally complex intermediates for next-generation medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel nucleoside analog drugs targeting viral infections and oncology.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) for hepatitis, HIV, and other viral diseases.
• Anticancer Agent Development: Employed in medicinal chemistry programs to create compounds that interfere with DNA/RNA synthesis in cancer cells.
• Bioconjugation and Probe Synthesis: The multiple azido groups enable click chemistry applications for labeling, bioconjugation, and creating molecular probes.
• Chemical Biology Studies: Acts as a tool compound for studying enzyme mechanisms and metabolic pathways involving nucleosides.
• Process Development & Scale-up: Used by fine chemical manufacturers for process optimization and GMP-scale production of advanced intermediates.

Basic Information

Product Name	(2S,3S,5R)-N-(4-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)BUTYL)-3-HYDROXY-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-CARBOXAMIDE
CAS No.	948916-04-9
Molecular Formula	C₂₇H₄₁N₁₅O₁₂
Molecular Weight	775.73 g/mol
Synonyms	1-(4-((2S,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-carboxamido)butyl)-3,5-diazido-2-((2S,3R,4R,5S,6R)-3-azido-6-(azidomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yloxy)-6-hydroxycyclohexylamine; 3'-Azido-3'-deoxythymidine (AZT) Triazole-Linked Glucoside Derivative; Multi-azido Functionalized Nucleoside Analog; Azido-Modified Thymidine Conjugate; Click Chemistry Nucleoside Building Block; CAS 948916-04-9
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and structural integrity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with every shipment. Our quality system is designed to support cGMP requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is strictly light-sensitive and should be handled under subdued lighting. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.