Description

L-Threoninamide, N-acetyl-L-isoleucyl-L-cysteinyl-L-valyl-1-methyl-L-tryptophyl-L-glutaminyl-L-α-aspartyl-L-tryptophylglycyl-L-alanyl-L-histidyl-L-arginyl-L-cysteinyl-, cyclic (2→12)-disulfide is a complex, high-purity synthetic peptide featuring a critical intramolecular disulfide bridge. This compound is of significant interest for advanced research and development in the life sciences sector due to its specific structural conformation and biological activity. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions focused on peptide-based therapeutics, receptor studies, and biochemical assays.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the discovery and development of novel peptide-based drugs and therapeutic agents.
• Biochemical Research: For studying protein-protein interactions, enzyme inhibition, and receptor binding assays where specific peptide sequences are required.
• Proteomics & Cell Signaling Studies: Used as a tool compound to investigate intracellular signaling pathways and biological mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in peptide synthesis and analysis.
• Bioconjugation & Probe Development: Potential use as a scaffold for developing labeled probes for imaging, diagnostics, or targeted delivery systems.

Basic Information

Product Name	L-Threoninamide, N-acetyl-L-isoleucyl-L-cysteinyl-L-valyl-1-methyl-L-tryptophyl-L-glutaminyl-L-α-aspartyl-L-tryptophylglycyl-L-alanyl-L-histidyl-L-arginyl-L-cysteinyl-, cyclic (2→12)-disulfide
CAS No.	934461-40-2
Molecular Formula	C84H120N24O22S2
Molecular Weight	1882.15 g/mol
Synonyms	Ac-Ile-Cys-Val-1-Me-Trp-Gln-Asp-Trp-Gly-Ala-His-Arg-Cys-Thr-NH2 (cyclic 2-12 disulfide); Cyclic [Cys2,Cys12]-Ac-Ile-Cys-Val-1-Me-Trp-Gln-Asp-Trp-Gly-Ala-His-Arg-Cys-Thr-NH2; Ac-ICV(1-Me)WQDWGAHRCT-NH2 (2-12 cyclic disulfide); N-Acetyl-cyclic(2-12)-[Cys2,Cys12]Ile-Cys-Val-(1-methyl)Tryptophan-Gln-Asp-Trp-Gly-Ala-His-Arg-Cys-Thr-amide; Synthetic peptide 934461-40-2; Cyclic disulfide peptide inhibitor; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our L-Threoninamide, N-acetyl-L-isoleucyl-L-cysteinyl-L-valyl-1-methyl-L-tryptophyl-L-glutaminyl-L-α-aspartyl-L-tryptophylglycyl-L-alanyl-L-histidyl-L-arginyl-L-cysteinyl-, cyclic (2→12)-disulfide is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, MS, and amino acid analysis, to ensure identity, purity, and conformity to specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.