Description

N-Succinimidyl 3-(perfluorohexyl)propionate, also known as 4,4,5,5,6,6,7,7,8,8,9,9,9-Tridecafluorononanoic acid N-succinimidyl ester or N-Succinimidyl 2H,2H,3H,3H-perfluorononanoate, is a highly specialized fluorinated active ester reagent. This compound is engineered to introduce hydrophobic, oleophobic, and chemically inert perfluoroalkyl chains onto target molecules via stable amide bond formation. It is an essential building block for researchers and manufacturers in advanced material science and life sciences, enabling the creation of surfaces and biomolecules with unique properties.

Application

• Bioconjugation & Protein Labeling: Used to covalently attach fluorinated tags to peptides, proteins, and antibodies for applications in diagnostics, imaging, and therapeutic agent development.
• Surface Modification & Functionalization: Key reagent for creating superhydrophobic and oleophobic coatings on glass, metals, polymers, and textiles for stain-resistant, self-cleaning, and anti-fouling surfaces.
• Polymer & Material Science: Serves as a monomer or cross-linker in the synthesis of fluorinated polymers, resins, and composites with enhanced chemical resistance, thermal stability, and low surface energy.
• Chromatography & Separation Media: Used to derivatize stationary phases (e.g., silica gel, resins) to create highly selective reverse-phase or affinity chromatography materials for analytical and preparative separations.
• Fluorous Chemistry & Synthesis: Enables fluorous tagging strategies for simplifying purification in combinatorial chemistry, parallel synthesis, and catalyst recovery.
• Medical Device Coatings: Applied in the development of biocompatible coatings for implants and medical instruments to reduce protein adsorption and bacterial adhesion.
• Microelectronics & Nano-fabrication: Used in the functionalization of nanoparticles, quantum dots, and sensor surfaces to impart specific interfacial properties.

Basic Information

Product Name	N-Succinimidyl 3-(perfluorohexyl)propionate
CAS No.	932710-51-5
Molecular Formula	C13H8F13NO4
Molecular Weight	465.19 g/mol
Synonyms	4,4,5,5,6,6,7,7,8,8,9,9,9-Tridecafluorononanoic acid N-succinimidyl ester; N-Succinimidyl 2H,2H,3H,3H-perfluorononanoate; NHS ester of 3-(Perfluorohexyl)propionic acid; 3-(Perfluorohexyl)propionic acid N-hydroxysuccinimide ester; 2,5-Dioxopyrrolidin-1-yl 3-((1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluorohexyl)oxy)propanoate; Perfluoroalkyl NHS Ester; PFHP-NHS Ester
EINECS	Contact for details

Quality Control

Our N-Succinimidyl 3-(perfluorohexyl)propionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive applications. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (purity), identity confirmation, and impurity profiles. Our quality commitment supports compliance with research and development standards, and we can accommodate specific purity requirements for advanced material and bioconjugation projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at temperatures between -20°C to -10°C for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For extended storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0 %
Solubility	Soluble in DMF, DMSO, acetonitrile, and common polar aprotic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.