Description

2-Methyl-pentanoic Acid [1S-[1α(R*),3β,7β,8β(2S*,4S*),8aβ]]-3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-8-[2-[4-[[(1,1-diMethylethyl)diMethylsilyl]oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydro-7-Methyl-1-naphthalenyl Ester is a highly specialized, complex organic ester featuring multiple protected hydroxyl groups via tert-butyldimethylsilyl (TBDMS) ethers. This compound is a critical advanced pharmaceutical intermediate or building block in sophisticated multi-step organic syntheses, particularly in the development of complex natural products and active pharmaceutical ingredients (APIs). It is primarily required by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in cutting-edge medicinal chemistry and process development.

Application

• Advanced Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of complex drug candidates, particularly those with polycyclic or steroidal-like frameworks.
• Medicinal Chemistry Research: Used in the discovery and optimization phase for creating novel therapeutic agents, leveraging its protected functional groups for selective reactions.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for potential commercial drug production.
• Natural Product Synthesis: Acts as a sophisticated precursor in the total synthesis of complex natural products with significant biological activity.
• Chemical Biology Probes: Can be utilized to develop specialized molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A vital component for fine chemical companies offering bespoke synthesis services to the pharmaceutical and biotechnology industries.

Basic Information

Product Name	2-Methyl-pentanoic Acid [1S-[1α(R*),3β,7β,8β(2S*,4S*),8aβ]]-3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-8-[2-[4-[[(1,1-diMethylethyl)diMethylsilyl]oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydro-7-Methyl-1-naphthalenyl Ester
CAS No.	159224-68-7
Molecular Formula	C37H66O6Si2
Molecular Weight	663.1 g/mol (approx.)
Synonyms	(1S,3R,7R,8R,8aS)-3-[(tert-Butyldimethylsilyl)oxy]-8-[2-[4-[(tert-butyldimethylsilyl)oxy]-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylpentanoate; 2-Methylpentanoic acid ester with a complex TBDMS-protected decalin-dihydropyranone alcohol; TBDMS-protected decalin-dihydropyranone 2-methylpentanoate; CAS 159224-68-7; Complex silyl ether ester intermediate
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols suitable for research and pharmaceutical development. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and impurity profiles are provided. Our quality system supports compliance with cGMP standards where required for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.