Description

[1S-[1α,3α,4β,4aα,7β,8β(2S*,4S*)]]-2,2-DiMethylbutanoic Acid 4-Chloro-8-[2-[4-[[(1,1-diMethylethyl)diMethylsilyl]oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,4,4a,7,8,8a-octahydro-4a-hydroxy-3-[(hydroxyiMino)Methyl]-7-Methyl-1-naphthalenyl Ester is a complex, high-purity synthetic intermediate characterized by its intricate stereochemistry and functional groups. This compound is of significant value in advanced organic synthesis, particularly for constructing pharmacologically active molecules with precise stereochemical requirements. It is primarily required by research and development teams in the pharmaceutical and fine chemical industries for the development of novel therapeutic agents and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel, stereochemically complex active pharmaceutical ingredients (APIs).
• Advanced Organic Synthesis: Used in multi-step synthetic routes for constructing complex polycyclic frameworks and natural product derivatives.
• Medicinal Chemistry Research: Serves as a crucial precursor in structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry Development: Employed in scaling up synthetic pathways from laboratory to pilot plant scale for potential commercial production.
• Chiral Synthesis: Utilized in reactions requiring high stereoselectivity due to its defined multiple chiral centers.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) ether moiety can be leveraged in synthetic strategies requiring orthogonal protection of hydroxyl groups.

Basic Information

Item	Details
Product Name	[1S-[1α,3α,4β,4aα,7β,8β(2S*,4S*)]]-2,2-DiMethylbutanoic Acid 4-Chloro-8-[2-[4-[[(1,1-diMethylethyl)diMethylsilyl]oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,4,4a,7,8,8a-octahydro-4a-hydroxy-3-[(hydroxyiMino)Methyl]-7-Methyl-1-naphthalenyl Ester
CAS No.	123852-22-2
Molecular Formula	C₃₃H₅₂ClNO₆Si
Molecular Weight	622.31 g/mol
Synonyms	4-Chloro-8-[2-[4-[(tert-butyldimethylsilyl)oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,4,4a,7,8,8a-octahydro-4a-hydroxy-3-(hydroxyiminomethyl)-7-methyl-1-naphthalenyl 2,2-dimethylbutanoate; TBDMS-protected chlorinated naphthalene ester oxime; (1S,3S,4R,4aS,7R,8R)-4-Chloro-8-[2-[4-[(tert-butyldimethylsilyl)oxy]-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-4a-hydroxy-3-(hydroxyiminomethyl)-7-methyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl 2,2-dimethylbutanoate; CAS 123852-22-2; Complex Chlorinated Naphthalene Ester Intermediate; Stereo-defined Synthetic Intermediate
EINECS	Contact for details

Quality Control

Our [1S-[1α,3α,4β,4aα,7β,8β(2S*,4S*)]]-2,2-DiMethylbutanoic Acid 4-Chloro-8-[2-[4-[[(1,1-diMethylethyl)diMethylsilyl]oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,4,4a,7,8,8a-octahydro-4a-hydroxy-3-[(hydroxyiMino)Methyl]-7-Methyl-1-naphthalenyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in the original sealed container to prevent degradation. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.