Description

Ethyl (R)-3-Hydroxybutyrate is a high-purity chiral ester, a key intermediate in the synthesis of optically active pharmaceuticals and fine chemicals. Its value lies in its role as a versatile building block for introducing the (R)-3-hydroxybutyryl moiety, a structural motif found in numerous bioactive compounds. This product is essential for research and manufacturing in the pharmaceutical, agrochemical, and specialty chemical industries, where precise stereochemistry is critical for efficacy and regulatory approval.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the production of statins (cholesterol-lowering drugs), antibiotics, and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the manufacture of chiral pesticides and herbicides, where the specific enantiomer can significantly impact biological activity and environmental safety.
• Flavor and Fragrance Industry: Serves as a precursor for the synthesis of specific, high-value aroma compounds and flavoring agents.
• Biochemical Research: Employed as a standard or substrate in enzymatic studies and metabolic pathway research.
• Polymer Chemistry: Acts as a monomer or co-monomer for creating specialized biodegradable or functional polymers.
• Asymmetric Synthesis: A valuable starting material or auxiliary in catalytic asymmetric reactions to construct complex molecular architectures.

Basic Information

Product Name	Ethyl (R)-3-Hydroxybutyrate
CAS No.	24915-95-5
Molecular Formula	C6H12O3
Molecular Weight	132.16 g/mol
Synonyms	(R)-Ethyl 3-hydroxybutyrate; (R)-3-Hydroxybutyric acid ethyl ester; Ethyl (R)-(-)-3-hydroxybutyrate; (R)-(-)-Ethyl 3-hydroxybutanoate; D-(-)-Ethyl 3-hydroxybutyrate; Ethyl D-3-hydroxybutyrate; (3R)-3-Hydroxybutanoic acid ethyl ester; Ethyl (3R)-3-hydroxybutanoate
EINECS	Contact for details

Quality Control

Our Ethyl (R)-3-Hydroxybutyrate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. We provide comprehensive analytical data, including HPLC/GC assay, chiral purity (enantiomeric excess), and identification (IR, NMR). Certificates of Analysis (COA) documenting all specifications are available for every batch. Our quality commitment supports compliance in cGMP and ISO 9001 environments for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product may be hygroscopic; ensure containers are sealed after use to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (R)
Refractive Index (n20D)	1.419 - 1.423
Specific Rotation ([α]20D)	-20° to -24° (c=1, CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.