Description

Butanoic acid, 3-methyl-, (1S,3S,5Z,7R,8E,11R,13E,15S,17R,21R,23R,25S)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-en-25-yl ester is a highly complex, stereochemically defined macrolide ester derivative. This compound is of significant interest in advanced pharmaceutical research and development due to its intricate molecular architecture, which is characteristic of bioactive natural product derivatives. It serves as a critical intermediate or reference standard for scientists working in medicinal chemistry and pharmacology. Target users include R&D laboratories and production facilities in the pharmaceutical, biotechnology, and fine chemical sectors focused on novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthetic pathways of complex macrolide-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a reference compound or precursor in structure-activity relationship (SAR) studies and drug discovery programs.
• Biochemical Tool: Potential use as a probe or inhibitor in enzymatic and cellular assays to study specific biological pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in HPLC, LC-MS, or NMR analysis.
• Fine Chemical Synthesis: Intermediate for the custom synthesis of specialized, high-value chemical entities for research purposes.

Basic Information

Product Name	Butanoic acid, 3-methyl-, (1S,3S,5Z,7R,8E,11R,13E,15S,17R,21R,23R,25S)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-25-yl ester
CAS No.	102580-65-4
Molecular Formula	C46H70O17
Molecular Weight	895.04 g/mol
Synonyms	(25S)-25-[(2S)-2-Methylbutanoyl]oxy-rapamycin; 42-O-(2S,3S)-2-Methylbutyryl-rapamycin; 42-O-(2S,3S)-2-Methylbutanoyl-rapamycin; Temsirolimus Impurity; Temsirolimus Related Compound; Torisel Impurity; CCI-779 Intermediate; Rapamycin 42-Ester with (2S,3S)-2-Methylbutyric Acid
EINECS	Contact for details

Quality Control

This high-value chemical is produced and handled under strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) is provided, detailing assay, related substances, and residual solvents. Our quality protocols are designed to meet the exacting standards required for pharmaceutical R&D and regulatory submission support.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The container should be kept in a dry, well-ventilated area. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Any single unknown impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.