Description

Acetic acid (1R,3R,4R,7S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dioxa-bicyclo[2.2.1]hept-7-yl ester is a sophisticated nucleoside derivative and a key pharmaceutical intermediate used in advanced synthesis. This compound is critical for research and development in the production of modified oligonucleotides and nucleotide-based therapeutics. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of antiviral agents, mRNA components, and other novel biologic drugs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of modified nucleosides and nucleotides for antiviral and anticancer drug candidates.
• Oligonucleotide Synthesis: Used in the preparation of protected nucleoside phosphoramidites for solid-phase synthesis of DNA/RNA analogs.
• ProTide Technology: Serves as a precursor in the development of ProTide prodrugs, enhancing the cellular delivery of nucleotide analogs.
• Antiviral Research: Key starting material for research into nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds.
• mRNA Vaccine & Therapeutic Development: Employed in the research phase for creating modified cap analogs or nucleoside triphosphate precursors.
• Bioconjugation & Labeling: The reactive ester group allows for conjugation to biomolecules for diagnostic or targeted delivery applications.
• Chemical Biology Probes: Used to create probes for studying enzyme mechanisms and nucleic acid interactions.

Basic Information

Product Name	Acetic acid (1R,3R,4R,7S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dioxa-bicyclo[2.2.1]hept-7-yl ester
CAS No.	902452-83-9
Molecular Formula	C40H40N2O11
Molecular Weight	724.76 g/mol
Synonyms	1-[(2R,3R,4R,5R)-5-[Bis(4-methoxyphenyl)(phenyl)methoxy]methyl-3,4-dihydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione 3'-Acetate; 3'-O-Acetyl-5-methyluridine, 2',5'-protected with DMT; 5'-O-DMT-2'-O-acetyl-5-methyluridine; 5-Methyluridine derivative, DMT-protected acetate; DMT-2'-Ac-5-methyluridine; ProTide Intermediate; Nucleoside Acetyl Ester Intermediate; Antiviral Nucleoside Precursor
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control in facilities adhering to cGMP guidelines. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to ensure structural identity and purity. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C ± 5°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and potentially light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.