Description

Atrial Natriuretic Factor (5-27) (human) trifluoroacetate salt H-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-OH trifluoroacetate salt (Disulfide bond) is a synthetic peptide fragment corresponding to the biologically active core of the human atrial natriuretic peptide (ANP) hormone. This high-purity reference standard is essential for cardiovascular research, enabling the study of natriuresis, diuresis, and vasodilation mechanisms. It is a critical reagent for pharmaceutical R&D, biochemical assay development, and quality control in peptide synthesis.

Application

• Biomedical Research: Used as a reference standard in studies investigating the renin-angiotensin-aldosterone system (RAAS), blood pressure regulation, and heart failure pathophysiology.
• Pharmaceutical Development: Serves as a key intermediate or analytical standard in the research and development of novel cardiovascular therapeutics and diagnostic assays.
• Biochemical Assays: Employed in receptor binding studies, enzyme-linked immunosorbent assays (ELISAs), and radioimmunoassays (RIAs) to quantify ANP activity or for calibration purposes.
• Cell Culture & Physiology: Applied in in vitro models to study the cellular effects of ANP on vascular smooth muscle, renal cells, and other target tissues.
• Peptide Chemistry Reference: Acts as a high-purity benchmark for confirming synthesis protocols, purity analysis, and stability testing of related peptide compounds.

Basic Information

Product Name	Atrial Natriuretic Factor (5-27) (human) trifluoroacetate salt H-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-OH trifluoroacetate salt (Disulfide bond)
CAS No.	98929-56-7
Molecular Formula	C106H168N38O33S3 • xC2HF3O2
Molecular Weight	~2770.9 g/mol (Free base)
Synonyms	ANF (5-27), human; Atrial Natriuretic Peptide (5-27); ANP (5-27); hANP (5-27); Cardionatrin (5-27); Atriopeptin (5-27); Auriculin A (5-27); Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg (Disulfide bond) trifluoroacetate salt
EINECS	Contact for details

Quality Control

Our Atrial Natriuretic Factor (5-27) is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot is characterized using advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content is provided with every shipment to support your compliance and research integrity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.