Description

(2S,3S,4S,5R,6S)-methyl-6-(2-(3-(((9H-fluoren-9yl)methoxy)carbonyl-amino)propanamido)-4-(((4-nitrophenoxy)carbonyloxy)methyl)phenoxy)-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate is a sophisticated, multi-functional chemical building block designed for advanced synthetic applications. This compound matters because it integrates a protected glycosyl donor, a fluorenylmethyloxycarbonyl (Fmoc) protected amine, and an activated p-nitrophenyl carbonate ester, enabling precise, multi-step conjugation strategies in complex molecule assembly. It is primarily needed by research institutions and pharmaceutical developers engaged in the synthesis of glycoconjugates, prodrugs, and novel bioconjugates for therapeutic and diagnostic applications.

Application

• Glycoconjugate Synthesis: Serves as a key intermediate for constructing complex carbohydrate-protein or carbohydrate-small molecule conjugates.
• Prodrug Development: Utilized in designing targeted prodrug systems where the activated carbonate moiety facilitates controlled drug release.
• Peptide and Protein Modification: The Fmoc-protected amino linker allows for seamless integration into solid-phase peptide synthesis (SPPS) workflows for site-specific glycosylation or labeling.
• Bioconjugation and Linker Chemistry: Acts as a versatile heterobifunctional linker for coupling biomolecules (e.g., antibodies, enzymes) to other entities like drugs, dyes, or solid supports.
• Chemical Biology Probes: Used in the development of activity-based probes and diagnostic agents for studying biological processes.
• Material Science Functionalization: Applied to modify surfaces or polymers with bioactive carbohydrate motifs.

Basic Information

Item	Details
Product Name	(2S,3S,4S,5R,6S)-methyl-6-(2-(3-(((9H-fluoren-9yl)methoxy)carbonyl-amino)propanamido)-4-(((4-nitrophenoxy)carbonyloxy)methyl)phenoxy)-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate
CAS No.	894095-98-8
Molecular Formula	C48H44N2O17
Molecular Weight	920.87 g/mol
Synonyms	Fmoc-NH-PEG2-COO-PNP glycoside derivative; Methyl 6-[2-[3-[(9H-fluoren-9-ylmethoxy)carbonylamino]propanamido]-4-[[(4-nitrophenoxy)carbonyloxy]methyl]phenoxy]-3,4,5-tri-O-acetyl-α/β-D-glucopyranoside (mixture of anomers); Glycosyl p-nitrophenyl carbonate activated ester; Fmoc-amino-PEG2-acid p-nitrophenyl activated glycoside; Carbohydrate-based heterobifunctional crosslinker; CAS 894095-98-8
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of (2S,3S,4S,5R,6S)-methyl-6-(2-(3-(((9H-fluoren-9yl)methoxy)carbonyl-amino)propanamido)-4-(((4-nitrophenoxy)carbonyloxy)methyl)phenoxy)-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate is characterized and verified to meet stringent purity criteria suitable for research and development. Certificates of Analysis (COA) detailing identity, purity (HPLC), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.