Description

[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-4-[(1E,3S)-3-[[(1,1-diMethylethyl)dimethylsilyl]oxy]-5-phenyl-1-pentenyl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester is a sophisticated, high-purity synthetic intermediate featuring a complex molecular architecture. This compound is of significant value for its role in advanced organic synthesis, particularly in constructing intricate pharmacophores and chiral molecules. It is primarily needed by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates, particularly in oncology and antiviral research.
• Chiral Synthesis: Utilized as a key chiral precursor or auxiliary in asymmetric synthesis to introduce specific stereochemistry into target molecules.
• Prostaglandin & Eicosanoid Analog Development: Serves as a core structural component in the research and synthesis of prostaglandin and related bioactive lipid analogs.
• Complex Natural Product Synthesis: Employed in academic and industrial laboratories for the total synthesis of complex natural products with potential therapeutic benefits.
• Process Chemistry & Scale-Up: Used in process development for optimizing synthetic routes to complex molecules before commercial-scale manufacturing.
• Chemical Biology Probes: Acts as a starting material for creating specialized molecular probes to study biological pathways and enzyme functions.

Basic Information

Product Name	[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-4-[(1E,3S)-3-[[(1,1-diMethylethyl)dimethylsilyl]oxy]-5-phenyl-1-pentenyl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester
CAS No.	865087-09-8
Molecular Formula	C39H46O5Si
Molecular Weight	622.87 g/mol
Synonyms	(3aR,4R,5R,6aS)-4-[(1E,3S)-3-[(tert-Butyldimethylsilyl)oxy]-5-phenyl-1-penten-1-yl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl 4-Biphenylcarboxylate; 4-Biphenylcarboxylic Acid (3aR,4R,5R,6aS)-4-[(1E,3S)-3-[(tert-Butyldimethylsilyl)oxy]-5-phenyl-1-penten-1-yl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl Ester; TBS-protected Prostaglandin Intermediate; Biphenyl-4-carboxylic Acid Prostanoate Ester; CAS 865087-09-8; tert-Butyldimethylsilyl (TBS) Ether Prostaglandin Synthon.
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity for sensitive research and development applications. Our quality assurance includes comprehensive analytical characterization using techniques such as HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.