Description

[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-4-[(1E,3R)-3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-4-[ 3-(trifluoroMethyl)phenoxy]-1-butenyl]hexahydro-2-oxo-2H-cyclopenta[b] furan-5-yl ester is a sophisticated, high-purity synthetic intermediate characterized by its complex stereochemistry and functional group architecture. This compound is of critical importance in advanced pharmaceutical research and development, serving as a key building block for the synthesis of novel therapeutic agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for constructing complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the multi-step synthesis of potential drug candidates, particularly in oncology and metabolic disease research.
• Prostaglandin Analog Synthesis: Serves as a key precursor in the development of prostaglandin and prostacyclin receptor agonists, leveraging its cyclopentane[b]furanone core structure.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable functional groups (silyl ether, ester, trifluoromethyl phenoxy).
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale, requiring consistent high purity and stereochemical integrity.
• Chemical Biology Probe Development: Utilized as a tagged or functionalized core structure for creating molecular probes to study biological pathways and target engagement.

Basic Information

Product Name	[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-4-[(1E,3R)-3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-4-[ 3-(trifluoroMethyl)phenoxy]-1-butenyl]hexahydro-2-oxo-2H-cyclopenta[b] furan-5-yl ester
CAS No.	865087-08-7
Molecular Formula	C38H43F3O6Si
Molecular Weight	680.83 g/mol
Synonyms	4'-Carboxybiphenyl-4-yl (3aR,4R,5R,6aS)-4-[(1E,3R)-3-[(tert-butyldimethylsilyl)oxy]-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester; Biphenyl-4-carboxylic acid prostacyclin intermediate; TBS-protected prostaglandin intermediate; (3aR,4R,5R,6aS)-5-([1,1'-Biphenyl]-4-carboxyloxy)-4-[(1E,3R)-3-[(tert-butyldimethylsilyl)oxy]-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl]hexahydro-2H-cyclopenta[b]furan-2-one; CAS 865087-08-7; UNII-Contact for details; Prostanoid synthesis intermediate
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems to ensure batch-to-batch consistency and stereochemical purity essential for pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. Our quality protocols are designed to meet the exacting standards of cGMP for advanced intermediates and align with ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment to maintain stability due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Diastereomeric Purity (HPLC)	≥ 99.0% de
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.