Description

Carbamic acid, N-[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-, 1,1-dimethylethyl ester is a sophisticated, high-purity pharmaceutical intermediate designed for advanced research and development. This compound is critical for medicinal chemists and process development scientists working on novel therapeutic agents, particularly in kinase inhibitor programs. Its complex, multi-functional structure makes it a valuable key building block for synthesizing targeted active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, particularly in oncology and inflammatory disease research.
• Kinase Inhibitor Development: Used as a core scaffold or advanced intermediate in the research and process development of selective kinase inhibitors.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization campaigns in drug discovery laboratories.
• Process Chemistry & Scale-up: Supports route scouting, optimization, and cGMP manufacturing for clinical trial material and commercial API production.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development, qualification, and quality control of final APIs.
• Custom Synthesis Building Block: Provides a versatile, fluorinated chemical handle for constructing bespoke molecular libraries and novel chemical entities.

Basic Information

Product Name	Carbamic acid, N-[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-, 1,1-dimethylethyl ester
CAS No.	830346-51-5
Molecular Formula	C33H30F4N3O5
Molecular Weight	624.61 g/mol
Synonyms	tert-Butyl N-[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]-1-phenylethyl]carbamate; (R)-tert-Butyl (2-(5-(2-fluoro-3-methoxyphenyl)-3-((2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)carbamate; BMS-582949 Intermediate; BMS582949 Intermediate; BMS 582949 Related Compound; CAS 830346-51-5; (R)-BMS-582949 tert-Butyl Carbamate Precursor
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability for critical R&D and scale-up work. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development under cGMP guidelines for projects requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; containers should be kept in secondary packaging or amber glass to minimize light exposure during storage and handling.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.