Description

(2S)-2-Methylbutanoic Acid (1S,6R,7R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-6-hydroxy-7-Methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester is a high-purity, complex chiral ester of significant interest in advanced organic synthesis. This compound matters as a sophisticated chemical building block and potential intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in the synthesis of complex natural products and therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for complex molecule synthesis.
• Organic Synthesis Building Block: Used in advanced multi-step organic synthesis to construct intricate molecular architectures found in natural products and specialty chemicals.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in studies exploring new asymmetric catalytic reactions due to its defined stereochemistry.
• Medicinal Chemistry: Employed in the design and synthesis of compound libraries for biological screening and structure-activity relationship (SAR) studies.
• Reference Standard: Used as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Fine Chemical Production: Acts as a precursor in the manufacture of high-value specialty chemicals and agrochemicals requiring specific stereochemistry.

Basic Information

Product Name	(2S)-2-Methylbutanoic Acid (1S,6R,7R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-6-hydroxy-7-Methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester
CAS No.	87984-67-6
Molecular Formula	C23H34O6
Molecular Weight	406.52 g/mol
Synonyms	Lovastatin Related Compound E; (1S,6R,7R,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-6-hydroxy-7-methyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate; Monacolin J 2-Methylbutyrate; 2-Methylbutyric Acid (1S,6R,7R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-6-hydroxy-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester; Lovastatin Impurity E; 6α-Hydroxymonacolin L 2-Methylbutyrate
EINECS	Contact for details

Quality Control

Our (2S)-2-Methylbutanoic Acid (1S,6R,7R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-6-hydroxy-7-Methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.