Description

Cyclo[L-Ala-D-Ala-N-methyl-L-Leu-L-Leu-N-methyl-L-Val-N-methyl-α-[(1R,2S,4E)-1-hydroxy-2-methyl-4-hexenyl]-L-Gly-L-Val-N-methyl-Gly-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-] is a complex, high-purity cyclic peptide compound, also known as the core structure of the natural product Largazole. This molecule is of significant interest due to its potent and selective biological activity as a class I histone deacetylase (HDAC) inhibitor. It is primarily utilized by research institutions and pharmaceutical developers engaged in oncology research, epigenetics studies, and the development of novel therapeutic agents targeting cancer and other diseases.

Application

• Biomedical Research: Serves as a critical reference standard and active pharmaceutical ingredient (API) in cancer biology and epigenetics research.
• Drug Discovery & Development: Used as a lead compound or intermediate in the synthesis and optimization of novel HDAC inhibitor-based therapeutics.
• Biochemical Assays: Employed as a potent and selective inhibitor in enzymatic assays to study HDAC function and validate drug targets.
• Academic Research: Utilized in universities and research institutes for investigating chromatin remodeling, gene expression regulation, and cellular differentiation pathways.
• Preclinical Studies: Applied in in vitro and in vivo models to evaluate antitumor efficacy, pharmacokinetics, and mechanism of action.

Basic Information

Product Name	Cyclo[L-Ala-D-Ala-N-methyl-L-Leu-L-Leu-N-methyl-L-Val-N-methyl-α-[(1R,2S,4E)-1-hydroxy-2-methyl-4-hexenyl]-L-Gly-L-Val-N-methyl-Gly-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-]
CAS No.	83563-93-3
Molecular Formula	C54H94N12O10
Molecular Weight	1047.4 g/mol
Synonyms	Largazole; Largazole Cyclic Peptide; Largazole Core; HDAC Inhibitor Largazole; Cyclo(L-Ala-D-Ala-N-Me-L-Leu-L-Leu-N-Me-L-Val-N-Me-L-Val(1-OH-2-Me-4-hexenyl)-Gly-L-Val-N-Me-Gly-N-Me-L-Leu-L-Val-N-Me-L-Leu); [1S-[1R*,2S*,4E]]-N-[(3S,6S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S)-36-[(1S)-1-Methylethyl]-3,6,9,12,15,18,21,24,27,30,33-undecamethyl-1,4,7,10,13,16,19,22,25,28,31,34-dodecaoxo-2,5,8,11,14,17,20,23,26,29,32,35-dodecaazacyclooctatriacontyl]-2-methyl-4-hexenamide
EINECS	Contact for details

Quality Control

Our Cyclo[L-Ala-D-Ala-N-methyl-L-Leu-L-Leu-N-methyl-L-Val-N-methyl-α-[(1R,2S,4E)-1-hydroxy-2-methyl-4-hexenyl]-L-Gly-L-Val-N-methyl-Gly-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-] is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting research reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.