Description

(Z)-2-Methyl-2-butenoic acid [(3aR,4S,6R,11R,11aS)-2,3,3a,4,5,6,7,10,11,11a-decahydro-11-hydroxy-6-methyl-3,10-bis(methylene)-2,7-dioxo-6,9-epoxycyclodeca[b]furan-4-yl] ester is a high-purity, complex sesquiterpene lactone derivative with significant synthetic utility. This compound serves as a critical advanced intermediate for the research and development of novel bioactive molecules. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for its unique structural framework.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and anti-inflammatory research.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to its complex, functionalized core.
• Natural Product Synthesis: Serves as a sophisticated precursor in the total or semi-synthesis of complex natural products and their analogs.
• Biochemical Probe Development: Utilized in the creation of specialized probes for studying biological pathways and target engagement.
• Fine Chemical Production: Employed in multi-step synthetic routes to produce high-value, low-volume specialty chemicals.

Basic Information

Product Name	(Z)-2-Methyl-2-butenoic acid [(3aR,4S,6R,11R,11aS)-2,3,3a,4,5,6,7,10,11,11a-decahydro-11-hydroxy-6-methyl-3,10-bis(methylene)-2,7-dioxo-6,9-epoxycyclodeca[b]furan-4-yl] ester
CAS No.	80377-52-2
Molecular Formula	C21H24O7
Molecular Weight	388.41 g/mol
Synonyms	2-Methyl-2-butenoic acid, (3aR,4S,6R,11R,11aS)-2,3,3a,4,5,6,7,10,11,11a-decahydro-11-hydroxy-6-methyl-3,10-bis(methylene)-2,7-dioxo-6,9-epoxycyclodeca[b]furan-4-yl ester, (Z)-; Parthenolide derivative; Parthenolide ester; 2-Methylcrotonic acid parthenolide ester; (Z)-Tiglic acid parthenolide ester; Sesquiterpene lactone ester; 80377-52-2
EINECS	Contact for details

Quality Control

Our (Z)-2-Methyl-2-butenoic acid parthenolide ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent condensation. The compound is moisture-sensitive and should be handled under an inert atmosphere when appropriate.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.