Description

Amyloid Bri Protein (1-23) trifluoroacetate salt H-Glu-Ala-Ser-Asn-Cys-Phe-Ala-Ile-Arg-His-Phe-Glu-Asn-Lys-Phe-Ala-Val-Glu-Thr-Leu-Ile-Cys-Ser-OH trifluoroacetate salt (Disulfide bond) is a synthetic peptide fragment corresponding to residues 1-23 of the amyloid Bri protein, provided as a trifluoroacetate salt with an intramolecular disulfide bond. This high-purity reference standard is critical for neuroscience research, particularly in the study of protein misfolding disorders and cerebral amyloid angiopathy. It is an essential tool for academic institutions, pharmaceutical R&D labs, and diagnostic developers focused on understanding disease mechanisms and developing targeted therapies.

Application

• Biomedical Research: Used as a key reference standard in studies of amyloidogenesis, protein aggregation, and the pathophysiology of Familial British Dementia (FBD).
• Assay Development: Serves as a critical calibrant and control in the development of immunoassays (ELISA, Western Blot) and biochemical assays for detecting amyloid Bri protein.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify and validate potential inhibitors of amyloid Bri aggregation and toxicity.
• Structural Biology: Provides a defined substrate for spectroscopic studies (NMR, CD) and crystallography to elucidate the peptide's structure and interaction with other molecules.
• Toxicology Studies: Used in cellular and animal models to investigate the neurotoxic effects of amyloid Bri deposition and evaluate therapeutic interventions.
• Diagnostic Reagent Production: Acts as an immunogen for generating specific antibodies or as a standard for quality control in diagnostic kit manufacturing.

Basic Information

Product Name	Amyloid Bri Protein (1-23) trifluoroacetate salt H-Glu-Ala-Ser-Asn-Cys-Phe-Ala-Ile-Arg-His-Phe-Glu-Asn-Lys-Phe-Ala-Val-Glu-Thr-Leu-Ile-Cys-Ser-OH trifluoroacetate salt (Disulfide bond)
CAS No.	717122-86-6
Molecular Formula	C₁₁₈H₁₇₈N₃₄O₃₈S₂ • xC₂HF₃O₂
Molecular Weight	~2690.9 g/mol (Free base)
Synonyms	ABri (1-23) peptide; Amyloid Bri Peptide Fragment 1-23; ABri Peptide (1-23), TFA salt; H-Glu-Ala-Ser-Asn-Cys-Phe-Ala-Ile-Arg-His-Phe-Glu-Asn-Lys-Phe-Ala-Val-Glu-Thr-Leu-Ile-Cys-Ser-OH (Disulfide bridge); Bri2 (1-23); ITM2B (1-23) peptide; Familial British Dementia Peptide; Synthetic ABri Fragment
EINECS	Contact for details

Quality Control

Our Amyloid Bri Protein (1-23) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Composition	Within ± 10% of theoretical
Single Disulfide Bond	Confirmed
Solubility	Soluble in water or dilute acetic acid
Water Content (KF)	≤ 5.0%
Trifluoroacetate Content	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.