Description

(E)-2-Hydroxymethyl-2-butenoic acid [(3aS,4S,5S,6R,10Z,11aR)-2,3,3a,4,5,6,7,11a-octahydro-5-hydroxy-6,10-dimethyl-3-methylene-2,7-dioxo-6,9-epoxycyclodeca[b]furan-4-yl] ester is a complex, high-purity sesquiterpene lactone derivative with significant biological activity. This compound is valued for its role as a key synthetic intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies focused on developing novel therapeutic agents, particularly in the fields of oncology and immunology.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of complex drug candidates, particularly those with anti-inflammatory or anti-cancer properties.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related active pharmaceutical ingredients (APIs) and natural product extracts.
• Biochemical Research: Employed in life science research to study cellular signaling pathways, enzyme inhibition, and structure-activity relationships (SAR) of sesquiterpene lactones.
• Natural Product Chemistry: Serves as a derivative or analog for the study and synthesis of naturally occurring sesquiterpene lactones found in medicinal plants.
• Process Development: Used in scaling up synthetic routes and optimizing production processes for high-value, low-volume specialty chemicals.

Basic Information

Product Name	(E)-2-Hydroxymethyl-2-butenoic acid [(3aS,4S,5S,6R,10Z,11aR)-2,3,3a,4,5,6,7,11a-octahydro-5-hydroxy-6,10-dimethyl-3-methylene-2,7-dioxo-6,9-epoxycyclodeca[b]furan-4-yl] ester
CAS No.	76235-74-0
Molecular Formula	C21H26O8
Molecular Weight	406.43 g/mol
Synonyms	Alantolactone 2-methylbut-2-enoate; Isoalantolactone ester derivative; (E)-2-(Hydroxymethyl)but-2-enoic acid alantolactone ester; Helenalin derivative; 6,9-Epoxy-6,10-dimethyl-3-methylene-2,7-dioxo-4-[(E)-2-(hydroxymethyl)but-2-enoyloxy]cyclodeca[b]furan-5-ol; 76235-74-0; Sesquiterpene lactone ester
EINECS	Contact for details

Quality Control

Our (E)-2-Hydroxymethyl-2-butenoic acid alantolactone ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) documenting identity, purity, and all relevant specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.