Description

4-acetyloxy-2-methyl-6-[[3,5,12-trihydroxy-10-methoxy-3-[2-[(4-methoxyphenyl)-diphenyl-methoxy]acetyl]-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]oxan-3-yl] acetate is a sophisticated, high-purity chemical intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it serves as a critical building block in the production of complex therapeutic agents, particularly within the anthracycline class. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing and producing next-generation medications.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent anthracycline-based chemotherapeutic agents and antibiotics.
• Research & Development: Used in academic and industrial laboratories for studying structure-activity relationships (SAR) and developing novel drug candidates with modified pharmacological profiles.
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) requiring complex glycosidic and ester functionalities.
• Biochemical Research: May serve as a tool compound for investigating DNA intercalation mechanisms and topoisomerase inhibition in biochemical assays.
• Fine Chemical Synthesis: Utilized as a specialized intermediate for constructing complex molecular architectures in custom synthesis and contract manufacturing projects.

Basic Information

Product Name	4-acetyloxy-2-methyl-6-[[3,5,12-trihydroxy-10-methoxy-3-[2-[(4-methoxyphenyl)-diphenyl-methoxy]acetyl]-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]oxan-3-yl] acetate
CAS No.	73113-86-7
Molecular Formula	C54H49NO15
Molecular Weight	951.97 g/mol
Synonyms	Doxorubicin derivative intermediate; 4'-O-Acetyl-4-demethoxydaunorubicin-14-O-hemiadipate DMT ether; 4'-O-Acetyl-4-demethoxy-7-O-[2-[(4-methoxyphenyl)diphenylmethoxy]acetyl]adriamycin; Doxorubicin-14-hemiadipate 4'-acetate DMT ether; Adriamycin derivative; 4-Demethoxydaunorubicin intermediate; Anthracycline glycoside ester; 1H-Tetracen-1-one derivative
EINECS	Contact for details

Quality Control

Our 4-acetyloxy-2-methyl-6-[[3,5,12-trihydroxy-10-methoxy-3-[2-[(4-methoxyphenyl)-diphenyl-methoxy]acetyl]-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]oxan-3-yl] acetate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for sensitive pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The container should be kept in a dry, well-ventilated area. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.