Description

Cyclo[Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-[[(2S,3R,4R,6E)-3-hydroxy-2-methylamino-4-methyl-6-octenoyl]-L-Val-]] is a complex, cyclic depsipeptide compound of significant interest in advanced pharmaceutical research and development. Its intricate structure, featuring multiple N-methylated amino acids and a unique hydroxyoctenoyl side chain, makes it a valuable scaffold for studying peptide conformation, stability, and biological activity. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel bioactive molecules, particularly in oncology and antimicrobial therapy. The CAS number for this compound is 63775-93-9.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel peptide-based therapeutics.
• Oncology Drug Discovery: Investigated for its potential as a cytotoxic agent or as a targeting moiety in antibody-drug conjugates (ADCs) due to its complex, cell-penetrating structure.
• Antimicrobial Agent Development: Explored for its activity against resistant bacterial strains, given the structural similarities to certain natural product antibiotics.
• Chemical Biology Probes: Used as a molecular tool to study protein-protein interactions, enzyme inhibition, and cellular signaling pathways.
• Peptide Chemistry & Conformational Studies: Provides a model compound for academic and industrial research into cyclic peptide stability, membrane permeability, and synthetic methodology.
• Process Development & Scale-up: Acts as a critical material for optimizing synthetic routes and purification processes in pilot-scale manufacturing.

Basic Information

Item	Details
Product Name	Cyclo[Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-[[(2S,3R,4R,6E)-3-hydroxy-2-methylamino-4-methyl-6-octenoyl]-L-Val-]]
CAS No.	63775-93-9
Molecular Formula	C58H100N12O13
Molecular Weight	1149.5 g/mol (approx.)
Synonyms	Cyclo(3-hydroxy-2-methylamino-4-methyl-6-octenoyl-L-Val-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val); L-Val- derivative of Cyclosporin-like depsipeptide; [Sar1, N-MeLeu4,6,7, N-MeVal8,10]-Cyclosporin A fragment; Depsipeptide Research Compound 63775-93-9; Complex Cyclic Peptide Ester
EINECS	Contact for details

Quality Control

Our Cyclo[Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-[[(2S,3R,4R,6E)-3-hydroxy-2-methylamino-4-methyl-6-octenoyl]-L-Val-]] is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques such as HPLC, MS, and NMR to ensure structural identity and high purity, meeting the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled temperature, ideally between 2°C and 8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.