Description

Dermcidin-1L (human) trifluoroacetate salt H-Ser-Ser-Leu-Leu-Glu-Lys-Gly-Leu-Asp-Gly-Ala-Lys-Lys-Ala-Val-Gly-Gly-Leu-Gly-Lys-Leu-Gly-Lys-Asp-Ala-Val-Glu-Asp-Leu-Glu-Ser-Val-Gly-Lys-Gly-Ala-Val-His-Asp-Val-Lys-Asp-Val-Leu-Asp-Ser-Val-Leu-OH trifluoroacetate salt is a synthetic peptide corresponding to the human antimicrobial peptide dermcidin, provided as a high-purity trifluoroacetate salt. This compound is of significant interest for its role in innate immunity and its potential as a research tool for studying skin defense mechanisms and developing novel antimicrobial agents. It is primarily utilized by researchers in pharmaceutical R&D, biotechnology, and academic institutions focused on immunology, dermatology, and peptide-based therapeutics.

Application

• Biomedical Research: Fundamental studies on the mechanism of action, structure-activity relationships (SAR), and antimicrobial properties of human dermcidin.
• Drug Discovery: Serving as a reference standard or lead compound in the development of new anti-infective and immunomodulatory peptide therapeutics.
• Innate Immunity Studies: Investigating the role of antimicrobial peptides in skin barrier function, host defense, and inflammatory responses.
• Biochemical Assay Development: Use as a critical reagent in establishing bioassays for antimicrobial activity screening or potency testing.
• Analytical Standard: Acting as a certified reference material for the qualitative and quantitative analysis (e.g., via HPLC, MS) of dermcidin-related samples.
• Cosmeceutical Research: Exploration of potential applications in skincare formulations targeting microbiome balance and skin health.

Basic Information

Product Name	Dermcidin-1L (human) trifluoroacetate salt H-Ser-Ser-Leu-Leu-Glu-Lys-Gly-Leu-Asp-Gly-Ala-Lys-Lys-Ala-Val-Gly-Gly-Leu-Gly-Lys-Leu-Gly-Lys-Asp-Ala-Val-Glu-Asp-Leu-Glu-Ser-Val-Gly-Lys-Gly-Ala-Val-His-Asp-Val-Lys-Asp-Val-Leu-Asp-Ser-Val-Leu-OH trifluoroacetate salt
CAS No.	478898-18-9
Molecular Formula	C192H317N55O64 • xC2HF3O2
Molecular Weight	~4330.0 g/mol (free peptide)
Synonyms	Dermcidin-1L; DCD-1L; Human Dermcidin Peptide (1-48); Antimicrobial Peptide DCD-1; Dermcidin (human); SSL-48; Preproteolysin; Dermcidin precursor protein (48 aa fragment); Sweat antimicrobial peptide DCD-1L; CAS 478898-18-9
EINECS	Contact for details

Quality Control

Our Dermcidin-1L (human) trifluoroacetate salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from multiple orthogonal methods including HPLC, MS, and amino acid analysis. We support research and development requiring high-integrity peptide standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.