Description

(2S)-2-[[(4S)-4-[[(4S)-4-[[(4S)-4-[[(4S)-4-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]amino]-4-carboxy-butanoyl]amino]-4-carboxy-butanoyl]amino]-4-carboxy-butanoyl]amino]-4-carboxy-butanoyl]amino]pentanedioic acid is a high-purity, complex folate derivative with significant biochemical relevance. This compound is critical for advanced research and development in pharmaceutical synthesis and life sciences, where precise molecular structure and purity are paramount. It serves as a key intermediate or reference standard for researchers in drug discovery, enzymology, and the development of novel therapeutic agents targeting folate-dependent pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel folate analogs and targeted chemotherapeutic agents.
• Biochemical Research: Used as a high-purity substrate or inhibitor in enzymatic studies related to folate metabolism and one-carbon transfer reactions.
• Reference Standard: Employed as an analytical standard in HPLC, LC-MS, and NMR for quality control and method validation in pharmaceutical analysis.
• Drug Discovery: A key compound in screening libraries for the development of new drugs targeting dihydrofolate reductase (DHFR) and other folate pathway enzymes.
• Nutritional Science Research: Used in advanced studies investigating the metabolism and cellular uptake of complex folate derivatives.

Basic Information

Item	Details
Product Name	(2S)-2-[[(4S)-4-[[(4S)-4-[[(4S)-4-[[(4S)-4-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]amino]-4-carboxy-butanoyl]amino]-4-carboxy-butanoyl]amino]-4-carboxy-butanoyl]amino]-4-carboxy-butanoyl]amino]pentanedioic acid
CAS No.	41432-72-8
Molecular Formula	C₄₆H₅₂N₁₂O₂₁
Molecular Weight	1125.0 g/mol (approx.)
Synonyms	Pteroic acid-γ-glutamyl-γ-glutamyl-γ-glutamyl-γ-glutamyl-glutamic acid; PteGlu-γ-Glu-γ-Glu-γ-Glu-γ-Glu; Tetraglutamyl Pteroic Acid; Folate Pentaglutamate Derivative; NSC 113928; 4-{4-[4-(4-{2-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](formyl)amino}benzoyl)amino]-4-carboxybutanamido}-4-carboxybutanamido)-4-carboxybutanamido]-4-carboxybutanamido}pentanedioic acid
EINECS	Contact for details

Quality Control

Our (2S)-2-[[(4S)-4-[[(4S)-4-[[(4S)-4-[[(4S)-4-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]amino]-4-carboxy-butanoyl]amino]-4-carboxy-butanoyl]amino]-4-carboxy-butanoyl]amino]-4-carboxy-butanoyl]amino]pentanedioic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.