Description

5-Hydroxydopamine Hydrochloride is a specialized neurochemical research compound and a selective neurotoxin for catecholaminergic neurons. Its primary value lies in its ability to induce chemical sympathectomy, making it a critical tool for studying the autonomic nervous system, neurodegenerative processes, and cardiovascular pharmacology. This product is essential for researchers and developers in pharmaceutical R&D, neuroscience, and academic laboratories focused on models of Parkinson's disease, hypertension, and autonomic dysfunction.

Application

• Neuroscience Research: Selective chemical ablation of peripheral sympathetic nerves and central catecholamine neurons for functional studies.
• Pharmacological Modeling: Creating animal models of autonomic failure, orthostatic hypotension, and neurodegenerative diseases like Parkinson's.
• Cardiovascular Research: Investigating the role of sympathetic innervation in blood pressure regulation and heart function.
• Neurotoxicity Studies: Used as a reference standard to study mechanisms of oxidative stress and selective neuronal vulnerability.
• Drug Discovery & Development: Screening and evaluating potential neuroprotective agents and treatments for dysautonomias.
• Biochemical Assays: Serving as a substrate or standard in enzymatic studies related to catecholamine metabolism.

Basic Information

Product Name	5-Hydroxydopamine Hydrochloride
CAS No.	5720-26-3
Molecular Formula	C8H12ClNO3
Molecular Weight	205.64 g/mol
Synonyms	5-OHDA HCl; 2,4,5-Trihydroxyphenethylamine Hydrochloride; 6-Hydroxydopamine isomer; Oxidopamine Hydrochloride (related); 5-Hydroxy dopamine HCl; 3,4,5-Trihydroxyphenethylamine Hydrochloride; 5-Hydroxy-2-(3,4-dihydroxyphenyl)ethylamine Hydrochloride
EINECS	227-227-8

Quality Control

We supply 5-Hydroxydopamine Hydrochloride in high-purity grades suitable for sensitive research applications. Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and other analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its sensitivity to oxidation and moisture. For long-term storage, desiccate at -20°C. Allow the sealed container to reach room temperature before opening to minimize condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.