Description

Kainic Acid 2-Carboxy-3-Carboxymethyl-4-Isopropenylpyrrolidine is a potent neuroexcitatory analog of glutamate, widely recognized as a selective agonist for kainate receptors. This specificity makes it an indispensable research tool for studying excitatory neurotransmission, neurotoxicity, and neurological disorders. It is primarily utilized by pharmaceutical researchers, neuroscientists, and academic institutions engaged in neuropharmacology and the development of treatments for conditions like epilepsy and neurodegenerative diseases. The compound is supplied under stringent quality control to ensure reliable and reproducible experimental results.

Application

• Neuroscience Research: As a selective kainate receptor agonist for studying excitatory synaptic transmission, long-term potentiation (LTP), and neuronal plasticity.
• Neuropharmacology: Used to induce excitotoxicity in cellular and animal models to investigate mechanisms of neuronal cell death and screen potential neuroprotective agents.
• Drug Discovery: A critical reference standard and tool compound in the development and validation of novel therapeutics targeting glutamate receptors for epilepsy, ALS, and Alzheimer's disease.
• Physiological Studies: Employed in electrophysiology experiments to characterize and differentiate kainate receptor-mediated currents from other ionotropic glutamate receptor responses.
• Toxicology Research: Used to model seizure disorders and study the pathways of excitotoxin-induced brain injury.
• Biochemical Assays: Serves as a key ligand in receptor binding assays and competitive inhibition studies to determine receptor affinity and density.

Basic Information

Item	Details
Product Name	Kainic Acid 2-Carboxy-3-Carboxymethyl-4-Isopropenylpyrrolidine
CAS No.	58002-62-3
Molecular Formula	C10H15NO6
Molecular Weight	245.23 g/mol
Synonyms	Kainic Acid; Digenic Acid; α-Kainic Acid; (2S,3S,4S)-3-(Carboxymethyl)-4-(1-methylethenyl)-L-proline; 2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid; L-α-Kainic Acid
EINECS	Contact for details

Quality Control

Our Kainic Acid is manufactured and tested to meet the exacting standards required for advanced life science research. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research protocols. We adhere to a rigorous quality management system to guarantee batch-to-batch consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.