Description

n-[[[(1S)-1-Carboxy-3-Methylbutyl]Amino]Carbonyl]-L-Glutamic Acid is a high-purity, non-proteinogenic amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block and intermediate for the synthesis of complex bioactive molecules, including enzyme inhibitors and peptide mimetics. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require precise, high-quality intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Protease Inhibitor Development: Used as a core structural component in the design and synthesis of selective enzyme inhibitors.
• Peptidomimetic Chemistry: Serves as a building block for creating stable peptide analogs with enhanced pharmacokinetic properties.
• Biochemical Research: Employed in academic and industrial laboratories as a substrate or inhibitor in enzymatic studies and assay development.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing specialized, high-value chemical entities.

Basic Information

Product Name	n-[[[(1S)-1-Carboxy-3-Methylbutyl]Amino]Carbonyl]-L-Glutamic Acid
CAS No.	723331-20-2
Molecular Formula	C12H20N2O7
Molecular Weight	304.30 g/mol
Synonyms	N-[(S)-1-Carboxy-3-methylbutyl]carbamoyl-L-glutamic acid; (2S)-2-[[[(2S)-1-Hydroxy-4-methyl-1-oxopentan-2-yl]amino]carbonyl]amino]pentanedioic acid; L-Glutamic acid, N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]-; NSC 760439; A building block for protease inhibitors.
EINECS	Contact for details

Quality Control

Our n-[[[(1S)-1-Carboxy-3-Methylbutyl]Amino]Carbonyl]-L-Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.