Description

(2S)-2-Hydroxy-2-methyl-3-chloropropanoic acid (3aR,9S)-8α,9β-dihydroxy-9-(chloromethyl)-3,6-bis(methylene)-2-oxo-2,3,3aβ,4,5,6,6aβ,7,8,9,9aβ,9bα-dodecahydroazuleno[4,5-b]furan-4β-yl ester is a complex, high-purity chiral ester derivative with a fused azulene-furan core structure. This compound is of significant interest as a key synthetic intermediate or building block in advanced organic synthesis, particularly for the development of novel pharmaceutical candidates and bioactive molecules. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the synthesis of complex natural product analogs and specialized chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel drug candidates, particularly those with complex polycyclic frameworks.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) targeting various therapeutic areas.
• Organic Synthesis: Acts as a versatile intermediate for constructing complex molecular architectures found in natural products and specialty chemicals.
• Biochemical Research: Potential use in the development of enzyme inhibitors or probes due to its reactive functional groups and specific stereochemistry.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value, low-volume specialty chemicals for advanced applications.

Basic Information

Item	Detail
Product Name	(2S)-2-Hydroxy-2-methyl-3-chloropropanoic acid (3aR,9S)-8α,9β-dihydroxy-9-(chloromethyl)-3,6-bis(methylene)-2-oxo-2,3,3aβ,4,5,6,6aβ,7,8,9,9aβ,9bα-dodecahydroazuleno[4,5-b]furan-4β-yl ester
CAS No.	37006-36-3
Molecular Formula	C20H23Cl2O7
Molecular Weight	431.30 g/mol
Synonyms	8α,9β-Dihydroxy-9-(chloromethyl)-3,6-bis(methylene)-2-oxo-2,3,3a,4,5,6,6a,7,8,9,9a,9b-dodecahydroazuleno[4,5-b]furan-4-yl (2S)-2-hydroxy-2-methyl-3-chloropropanoate; (2S)-2-Hydroxy-2-methyl-3-chloropropionic acid (3aR,9S)-8α,9β-dihydroxy-9-(chloromethyl)-3,6-bis(methylene)-2-oxo-2,3,3a,4,5,6,6a,7,8,9,9a,9b-dodecahydroazuleno[4,5-b]furan-4-yl ester; Azuleno[4,5-b]furan-4β-ol, 8α,9β-dihydroxy-9-(chloromethyl)-3,6-bis(methylene)-2-oxododecahydro-, (2S)-2-hydroxy-2-methyl-3-chloropropanoate (ester); 37006-36-3; (3aR,9S)-8α,9β-Dihydroxy-9-(chloromethyl)-3,6-bis(methylene)-2-oxo-2,3,3a,4,5,6,6a,7,8,9,9a,9b-dodecahydroazuleno[4,5-b]furan-4-yl (2S)-2-hydroxy-2-methyl-3-chloropropanoate.
EINECS	Contact for details

Quality Control

Our (2S)-2-Hydroxy-2-methyl-3-chloropropanoic acid (3aR,9S)-8α,9β-dihydroxy-9-(chloromethyl)-3,6-bis(methylene)-2-oxo-2,3,3aβ,4,5,6,6aβ,7,8,9,9aβ,9bα-dodecahydroazuleno[4,5-b]furan-4β-yl ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, chiral purity, and impurities are provided with every shipment. We support custom synthesis and can tailor specifications to meet the stringent requirements of pharmaceutical development (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.