Description

Formamide, N-[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]- is a high-purity, advanced pharmaceutical intermediate with a complex, multi-ring structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily targeted at research institutions and pharmaceutical companies engaged in the development of new chemical entities, especially within oncology and antiviral drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those targeting specific enzyme inhibition.
• Drug Discovery & Development: Used in medicinal chemistry research for structure-activity relationship (SAR) studies and lead optimization processes.
• Protease Inhibitor Synthesis: Serves as a core scaffold in the development of novel protease inhibitors, a common target class for antiviral and anticancer therapies.
• Chemical Biology Research: Employed as a tool compound or a labeled analog in biochemical assays to study protein-ligand interactions.
• Custom Synthesis Building Block: Supplied to contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring high-fidelity chiral centers and fluorinated motifs.

Basic Information

Item	Details
Product Name	Formamide, N-[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-
CAS No.	2409132-63-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-[(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]formamide; (R)-N-(2-(5-(2-Fluoro-3-methoxyphenyl)-3-((2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)formamide; Fluorinated Dihydropyrimidinone Formamide Derivative; Advanced Fluorinated API Intermediate; CAS 2409132-63-2.
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive analytical package including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with each batch, documenting compliance with client-specific or in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time matches reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.