Description

1-Piperazinecarboxylic acid, 4-[(1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1,2-dihydro-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-2-oxopyrido[2,3-d]pyrimidin-4-yl]-3-methyl-, 1,1-dimethylethyl ester, (3S)- is a sophisticated, high-purity pharmaceutical intermediate designed for advanced drug development. This compound is critical for researchers and manufacturers requiring a reliable, high-quality building block for complex active pharmaceutical ingredients (APIs). It is primarily targeted at the pharmaceutical industry for the synthesis of novel therapeutic agents, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex, target-specific Active Pharmaceutical Ingredients (APIs).
• Oncology Drug Development: Used in the research and production of novel chemotherapeutic agents and targeted cancer therapies.
• Kinase Inhibitor Synthesis: Serves as a crucial precursor in the manufacture of kinase inhibitors, a major class of therapeutic compounds.
• Preclinical & Clinical Research: Provides a consistent and well-characterized material for drug discovery, preclinical studies, and clinical trial material (CTM) manufacturing.
• Process Chemistry & Scale-Up: Supports process research, optimization, and the scale-up from laboratory to commercial production batches.
• Custom Synthesis: Acts as a starting material for contract research and manufacturing organizations (CROs/CMOs) engaged in custom synthesis projects.

Basic Information

Product Name	1-Piperazinecarboxylic acid, 4-[(1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1,2-dihydro-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-2-oxopyrido[2,3-d]pyrimidin-4-yl]-3-methyl-, 1,1-dimethylethyl ester, (3S)-
CAS No.	2387708-38-3
Molecular Formula	C34H35F2N5O5
Molecular Weight	631.67 g/mol
Synonyms	(3S)-tert-Butyl 4-((R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(propan-2-yl)pyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate; PF-07321332 tert-butyl ester intermediate; Nirmatrelvir tert-butyl ester intermediate (stereospecific); Paxlovid (Nirmatrelvir) key intermediate; SARS-CoV-2 3CL protease inhibitor intermediate; (3S)-1-Boc-3-methyl-4-((R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-isopropylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)piperazine
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality systems. Every batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.