Description

2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3S)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]- is a sophisticated, high-purity chemical intermediate designed for advanced pharmaceutical synthesis. This compound is critical for research and development in targeted therapeutic areas, offering a key building block for complex molecular architectures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel, high-value active pharmaceutical ingredients (APIs).
• Oncology Research: Used in the research and development of targeted cancer therapies due to its specific structural motifs.
• Kinase Inhibitor Development: A key building block for creating potent and selective kinase inhibitors, a major class of therapeutic agents.
• Preclinical & Clinical Trial Material: Supplied under stringent quality control for use in non-clinical studies and the manufacture of clinical trial materials.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production of candidate drugs.
• Custom Synthesis & Contract Manufacturing: Provided to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3S)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-
CAS No.	2370013-49-1
Molecular Formula	C30H38ClFN8O3
Molecular Weight	613.13 g/mol
Synonyms	N-[5-[[4-[[5-Chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3S)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-2-propenamide; (S)-N-(5-((4-((5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)phenyl)amino)pyrimidin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide; Advanced Kinase Inhibitor Intermediate; Pharmaceutical Building Block 2370013-49-1; Acrylamide derivative intermediate
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines where applicable, ensuring traceability and reproducibility. Every batch undergoes comprehensive analytical characterization, including HPLC for purity and chiral integrity, to meet exacting customer specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, and regulatory support documentation (DMF, CMC) can be discussed upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep the container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.