Description

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- is a high-purity, complex heterocyclic organic compound designed for advanced research and development. This molecule is of significant interest as a key pharmaceutical intermediate or active pharmaceutical ingredient (API) precursor in the discovery of novel therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and contract research organizations (CROs) focused on oncology, kinase inhibition, and other targeted disease pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel small-molecule drug candidates.
• Kinase Inhibitor Research: Used in the development and screening of potential kinase inhibitors for cancer and inflammatory diseases.
• Biochemical Assay Development: Employed as a reference standard or probe compound in high-throughput screening (HTS) and mechanism-of-action studies.
• Medicinal Chemistry: Provides a sophisticated scaffold for structure-activity relationship (SAR) optimization in drug discovery programs.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under cGMP conditions for clinical trial material production.
• Academic Research: Used in university and institutional labs for fundamental chemical biology and pharmacology research.

Basic Information

Item	Details
Product Name	3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-
CAS No.	2272976-28-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	6-[(2',3'-Dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one; Spirocyclopropane-isoquinoline-pyrazolopyrimidinone derivative; Kinase inhibitor intermediate 2272976-28-8; API Intermediate CAS 2272976-28-8; Pyrazolopyrimidine-based scaffold; Heterocyclic amine derivative.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer material suitable for research and development under strict quality protocols. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles. For advanced applications, we can discuss supply under cGMP guidelines and compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.