Description

2-((S)-1-acryloyl-4-(7-(8-methylnaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile is a sophisticated, high-purity synthetic intermediate featuring a complex heterocyclic structure designed for targeted molecular interactions. This compound is of critical importance in modern pharmaceutical research and development, particularly for the synthesis of novel therapeutic agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on kinase inhibitors and other small-molecule drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of targeted kinase inhibitors for oncology and other therapeutic areas.
• Preclinical Drug Discovery: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Biochemical Research: Acts as a tool compound or a precursor for probes in biochemical and cellular assays to study specific biological pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	2-((S)-1-acryloyl-4-(7-(8-methylnaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile
CAS No.	2206736-04-9
Molecular Formula	C₃₃H₃₉N₇O₂
Molecular Weight	565.71 g/mol
Synonyms	Acrylonitrile, 2-[1-(1-oxo-2-propen-1-yl)-4-[7-(8-methyl-1-naphthalenyl)-2-[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-5,6,7,8-tetrahydro-4-pyrido[3,4-d]pyrimidinyl]-2-piperazinyl]-; (S)-2-(1-acryloyl-4-(7-(8-methylnaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile; Kinase Inhibitor Intermediate 2206736-04-9; Tetrahydropyridopyrimidine-acrylonitrile derivative; CAS 2206736-04-9
EINECS	Contact for details

Quality Control

Our 2-((S)-1-acryloyl-4-(7-(8-methylnaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the product label or COA. Keep the container sealed in a dry, well-ventilated place. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.