Description

Formamide, N-[3-[[2-cyano-4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indol-1-yl]methyl]bicyclo[1.1.1]pent-1-yl]- is a high-purity, complex organic intermediate designed for advanced pharmaceutical research and development. This compound is critical for medicinal chemistry programs targeting novel therapeutic pathways, offering a sophisticated building block for structure-activity relationship (SAR) studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of innovative small-molecule drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel, high-potency active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used in lead optimization and SAR studies to develop new drug candidates targeting specific enzymes or receptors.
• Kinase Inhibitor Development: Serves as a core structural component in the research and development of potent and selective kinase inhibitors.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Process Chemistry: Used in route scouting and scale-up studies for the efficient and reproducible synthesis of complex drug molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the global biopharma industry.

Basic Information

Item	Details
Product Name	Formamide, N-[3-[[2-cyano-4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indol-1-yl]methyl]bicyclo[1.1.1]pent-1-yl]-
CAS No.	2134169-43-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-[3-[[2-Cyano-4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indol-1-yl]methyl]bicyclo[1.1.1]pent-1-yl]formamide; Bicyclo[1.1.1]pentane-1-carboxamide derivative; Advanced kinase inhibitor intermediate; Complex heterocyclic formamide; Thienopyrimidine-indole conjugate
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems to ensure identity, purity, and consistency essential for sensitive research applications. Our analytical protocols utilize state-of-the-art techniques including HPLC, LC-MS, and NMR for comprehensive characterization. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming critical specifications such as purity, residual solvents, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	≤ 5.0% total
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.