Description

5H-Pyrrolo3,2-dpyrimidin-2-amine, 7-(3aS,4S,6R,6aR)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-4-(phenylmethoxy)-N,N,5-tris(phenylmethyl)- is a sophisticated nucleoside analog intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of next-generation nucleotide-based therapies.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside analog drugs targeting viral infections and oncology.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) for hepatitis, HIV, and other viral diseases.
• Anticancer Agent Development: Serves as a precursor in the creation of chemotherapeutic compounds that interfere with DNA/RNA synthesis in cancer cells.
• ProTide Technology: A key intermediate in the synthesis of phosphoramidate prodrugs (ProTides) designed to enhance cellular delivery and activation of nucleotide analogs.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of candidate drug molecules.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and cGMP manufacturing for clinical trial material and commercial API production.

Basic Information

Item	Details
Product Name	5H-Pyrrolo3,2-dpyrimidin-2-amine, 7-(3aS,4S,6R,6aR)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-4-(phenylmethoxy)-N,N,5-tris(phenylmethyl)-
CAS No.	299917-27-4
Molecular Formula	C48H58N4O5Si
Molecular Weight	799.1 g/mol
Synonyms	4-(Benzyloxy)-7-[(3aS,4S,6R,6aR)-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-4-yl]-N,N,5-tris(benzyl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine; 2-Amino-4-benzyloxy-7-[6-O-(tert-butyldimethylsilyl)-2,3-O-isopropylidene-β-D-ribofuranosyl]-5,7-dihydro-4H-pyrrolo[3,2-d]pyrimidine N,N,5-tribenzyl derivative; GS-6620 intermediate; Nucleoside ProTide intermediate; TBDMS-protected nucleoside analog.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting identity, purity, and impurity profiles. We support compliance with ICH guidelines for stability and impurity characterization.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere at -20°C. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.