Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-(1,1-dimethylethoxy)-5-(phenylmethoxy)methyl-5H-pyrrolo3,2-dpyrimidin-7-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a sophisticated, high-purity chemical intermediate designed for advanced synthetic applications. This compound is critical for researchers and process chemists requiring precise building blocks for complex molecular architectures, particularly in pharmaceutical development. Its complex structure, featuring multiple protected functional groups, makes it an essential reagent for the synthesis of nucleoside analogs and other active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer therapies.
• Antiviral Drug Research: Used in the research and development of prodrugs targeting viral polymerases, such as those for hepatitis and other viral infections.
• ProTide Technology: Serves as a critical precursor in the synthesis of ProTide prodrugs, a technology platform used to enhance the cellular delivery and efficacy of nucleotide analogs.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization campaigns to develop new chemical entities.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials and commercial APIs.
• Bioconjugation & Labeling: Potential use in creating labeled probes or conjugates for diagnostic and research purposes due to its modifiable functional groups.

Basic Information

Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-(1,1-dimethylethoxy)-5-(phenylmethoxy)methyl-5H-pyrrolo3,2-dpyrimidin-7-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	299917-26-3
Molecular Formula	C41H55N3O8Si
Molecular Weight	745.99 g/mol
Synonyms	tert-Butyl ((3aS,4S,6R,6aR)-4-(4-((tert-butoxy)methyl)-5-((benzyloxy)methyl)-7H-pyrrolo[3,2-d]pyrimidin-7-yl)-2,2-dimethyl-6-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuro[3,4-d][1,3]dioxol-5-yl)carboxylate; (3aS,4S,6R,6aR)-tert-Butyl 4-(4-((tert-butoxy)methyl)-5-((benzyloxy)methyl)-7H-pyrrolo[3,2-d]pyrimidin-7-yl)-2,2-dimethyl-6-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuro[3,4-d][1,3]dioxole-5-carboxylate; 299917-26-3; Advanced Nucleoside Intermediate; ProTide Intermediate; TBS-protected nucleoside precursor.
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical research and development. Our quality system includes in-process controls and final release testing against comprehensive specifications. A detailed Certificate of Analysis (COA) is provided with each batch, documenting identity, purity, and impurity profiles. We support development from non-GMP research quantities through to cGMP-grade material for clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.