Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-6-4-(phenylmethoxy)-5-(phenylmethoxy)methyl-5H-pyrrolo3,2-dpyrimidin-7-yl-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)- is a highly specialized, advanced pharmaceutical intermediate with a complex, multi-functional molecular architecture. Its core value lies in its role as a critical building block for the synthesis of novel nucleoside analogs and other high-value active pharmaceutical ingredients (APIs). This compound is essential for research and development laboratories and production facilities focused on antiviral, anticancer, and other therapeutic areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex nucleoside and nucleotide analogs for antiviral and anticancer drug candidates.
• Antiviral Drug Development: Used in research and production of novel therapeutics targeting viruses such as hepatitis, herpes, and other DNA/RNA viruses.
• Oncology Research: Serves as a building block for creating purine and pyrimidine derivatives that act as enzyme inhibitors or antimetabolites in cancer treatment pathways.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes from laboratory-scale research to commercial manufacturing of target APIs.
• Protease & Polymerase Inhibitor Synthesis: Integral to constructing the core scaffold of molecules designed to inhibit specific viral or cellular enzymes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific novel chemical entities (NCEs).

Basic Information

Item	Detail
Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-6-4-(phenylmethoxy)-5-(phenylmethoxy)methyl-5H-pyrrolo3,2-dpyrimidin-7-yl-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)-
CAS No.	299917-25-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	tert-Butyl (3aR,4R,6S,6aS)-4-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-6-(4-((phenylmethoxy)methyl)-5-((phenylmethoxy)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,4-d][1,3]dioxole-5-carboxylate; Advanced Nucleoside Intermediate; (3aR,4R,6S,6aS)-tert-Butyl 4-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-6-(4,5-bis((benzyloxy)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,4-d][1,3]dioxole-5-carboxylate; Benzyl-Protected Pyrrolopyrimidine Intermediate; TBDMS-Protected Nucleoside Analog Precursor; CAS 299917-25-2
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality management systems, with process controls designed to ensure batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting identity, purity, and impurity profiles to support regulatory filings (e.g., Drug Master Files - DMFs) and GMP manufacturing where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) in a desiccator.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.