Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-6-4-(phenylmethoxy)-5-2-(trimethylsilyl)ethoxymethyl-5H-pyrrolo3,2-dpyrimidin-7-yl-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)- is a highly specialized, complex organic intermediate featuring multiple protecting groups, making it a critical building block for advanced synthetic chemistry. Its precise stereochemistry and functionalization enable the synthesis of sophisticated nucleoside analogs and heterocyclic compounds. This compound is essential for research and development in pharmaceutical and biotechnology sectors, particularly for medicinal chemists working on novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and development of novel antiviral and anticancer nucleoside analogs.
• Medicinal Chemistry Research: Serves as a sophisticated building block for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under GMP-like conditions.
• Bioconjugation & Probe Synthesis: The reactive ester and protected functionalities allow for the creation of labeled compounds for biochemical assays.
• Academic & Institutional Research: Enables cutting-edge organic synthesis projects focused on complex heterocycles and modified nucleosides.

Basic Information

Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-6-4-(phenylmethoxy)-5-2-(trimethylsilyl)ethoxymethyl-5H-pyrrolo3,2-dpyrimidin-7-yl-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)-
CAS No.	299917-23-0
Molecular Formula	C41H63N3O8Si2
Molecular Weight	782.13 g/mol
Synonyms	(3aR,4R,6S,6aS)-4-((tert-Butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydro-6-(4-(benzyloxy)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester; tert-Butyl (3aR,4R,6S,6aS)-4-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-6-(4-(benzyloxy)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)tetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; Advanced Nucleoside Intermediate; Protected Pyrrolopyrimidine Ester.
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity required for sensitive synthetic applications. Our quality system includes comprehensive analytical characterization using HPLC, NMR, and MS to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.