Description

5H-Pyrrolo[3,2-d]pyrimidine, 7-[(3aS,4S,6R,6aR)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxymethyl]tetrahydro-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyrrol-4-yl]-2-fluoro-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]- is a sophisticated nucleoside analog intermediate of significant importance in modern pharmaceutical research and development. This compound is specifically engineered for the synthesis of novel antiviral and anticancer therapeutics, offering a critical building block for targeted drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and advanced fine chemical manufacturers engaged in the development of next-generation nucleotide-based drugs.

Application

• Key Intermediate for Antiviral Drugs: Serves as a crucial precursor in the synthesis of experimental nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Oncology Research: Used in the development of targeted cancer therapies, particularly those involving nucleotide analogs that interfere with DNA/RNA synthesis in rapidly dividing cells.
• Prodrug Synthesis: Acts as a scaffold for creating prodrugs with enhanced bioavailability and targeted delivery mechanisms.
• Medicinal Chemistry & SAR Studies: Provides a versatile core structure for structure-activity relationship (SAR) studies to optimize potency and reduce toxicity.
• Bioconjugation & Labeling: The functionalized structure allows for potential use in creating labeled probes or conjugates for diagnostic and research purposes.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and cGMP-compliant manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	5H-Pyrrolo[3,2-d]pyrimidine, 7-[(3aS,4S,6R,6aR)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxymethyl]tetrahydro-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyrrol-4-yl]-2-fluoro-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]-
CAS No.	299917-20-7
Molecular Formula	C36H46FN3O6Si
Molecular Weight	663.86 g/mol
Synonyms	7-[(3aS,4S,6R,6aR)-6-[[(tert-Butyldimethylsilyl)oxy]methyl]tetrahydro-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyrrol-4-yl]-2-fluoro-4-(benzyloxy)-5-[(benzyloxy)methyl]-5H-pyrrolo[3,2-d]pyrimidine; 2-Fluoro-4,5-bis(benzyloxy)-7-[(3aS,4S,6R,6aR)-6-[[(tert-butyldimethylsilyl)oxy]methyl]-2,2-dimethyltetrahydro-4H-1,3-dioxolo[4,5-c]pyrrol-4-yl]-5H-pyrrolo[3,2-d]pyrimidine; TBDMS-protected fluorinated pyrrolopyrimidine nucleoside; 299917-20-7; Fluorinated pyrrolopyrimidine intermediate; Nucleoside analog intermediate with TBDMS and benzyl protecting groups.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability for critical research and development. Each lot is characterized using advanced analytical techniques including HPLC, NMR (1H, 13C, 19F), and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and analytical data is provided with every shipment. We support development from milligram to kilogram scale with quality protocols suitable for cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment to prevent degradation due to its hygroscopic and potentially light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.