Description

5H-Pyrrolo[3,2-d]pyrimidine, 5-(1,1-dimethylethyl)dimethylsilyl-7-((3aS,4S,6R,6aR)-6-(((1,1-dimethylethyl)dimethylsilyl)oxymethyl)tetrahydro-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyrrol-4-yl)-2-fluoro-4-(phenylmethoxy)- is a sophisticated, high-purity nucleoside analog intermediate critical for advanced pharmaceutical synthesis. This compound is engineered to provide a protected, reactive scaffold essential for the development of novel antiviral and anticancer therapeutics. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis of modified oligonucleotides and nucleotide-based active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antiviral drugs, particularly those targeting RNA viruses.
• Anticancer Drug Development: Used in research and production of nucleotide analogs designed to inhibit cancer cell proliferation.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase synthesis of modified DNA/RNA strands for therapeutic and diagnostic applications.
• Prodrug Synthesis: Employed in creating prodrug forms of nucleotide analogs to enhance bioavailability and targeting.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies in academic and industrial R&D labs.
• Pre-clinical & Clinical Trial Material: Supplied as a critical raw material for producing batches of investigational new drugs (INDs).

Basic Information

Item	Details
Product Name	5H-Pyrrolo[3,2-d]pyrimidine, 5-(1,1-dimethylethyl)dimethylsilyl-7-((3aS,4S,6R,6aR)-6-(((1,1-dimethylethyl)dimethylsilyl)oxymethyl)tetrahydro-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyrrol-4-yl)-2-fluoro-4-(phenylmethoxy)-
CAS No.	299917-18-3
Molecular Formula	C33H53FN4O5Si2
Molecular Weight	660.97 g/mol
Synonyms	2'-Deoxy-2'-fluoro-5'-O-(tert-butyldimethylsilyl)-3'-O-((3aS,4S,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydro-4H-1,3-dioxolo[4,5-c]pyrrol-4-yl)-5-methyluridine intermediate; 2'-F-5-Me-Uridine TBDMS protected intermediate; 5'-O-TBDMS-2'-fluoro-5-methyluridine-3'-O-(4-C-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolane-4-yl) derivative; Fluorinated pyrrolopyrimidine nucleoside; 299917-18-3; 5H-Pyrrolo[3,2-d]pyrimidine, TBDMS-protected fluoro derivative
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality management systems in facilities designed for advanced chemical synthesis. Every batch is subjected to comprehensive analytical testing including HPLC, NMR (1H and 13C), and mass spectrometry to confirm identity, purity, and isomeric composition. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and compliance with customer specifications for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This compound is moisture-sensitive; containers must be sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Diastereomeric Purity	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.