Description

1H-Pyrrolo3,2-dpyrimidine-2,4(3H,5H)-dione, 5-(1,1-dimethylethyl)dimethylsilyl-7-(3aS,4S,6R,6aR)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl- is a sophisticated, high-purity nucleoside analog intermediate of significant importance in pharmaceutical research and development. This compound is specifically engineered for use in the synthesis of modified oligonucleotides, which are critical for advanced therapeutic applications. It is an essential building block for research organizations and manufacturers focused on antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.

Application

• Pharmaceutical Intermediate: A key protected monomer in the solid-phase synthesis of therapeutic oligonucleotides.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) targeting genetic diseases.
• siRNA Synthesis: Serves as a critical precursor for the manufacture of small interfering RNA (siRNA) molecules for gene silencing applications.
• Research & Development: Employed in academic and industrial labs for studying nucleic acid chemistry and developing novel nucleotide analogs.
• Diagnostic Probe Synthesis: Utilized in creating labeled probes for genetic testing and molecular diagnostics.
• API Manufacturing: Acts as a high-value starting material or intermediate in the cGMP production of active pharmaceutical ingredients (APIs) for nucleic acid therapies.

Basic Information

Item	Details
Product Name	1H-Pyrrolo3,2-dpyrimidine-2,4(3H,5H)-dione, 5-(1,1-dimethylethyl)dimethylsilyl-7-(3aS,4S,6R,6aR)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-
CAS No.	299916-75-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(tert-Butyldimethylsilyl)-2'-O-(tert-Butyldimethylsilyl)-3'-O-[(3aS,4S,6R,6aR)-6-[(tert-Butyldimethylsilyloxy)methyl]-2,2-dimethyltetrahydro-4H-1,3-dioxolo[4,5-c]pyrrol-4-yl]uridine; 5'-O-TBDMS-2'-O-TBDMS-3'-O-ACE-Uridine; TBDMS-protected ACE-Uridine; 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-O-ACE-uridine; Protected Uridine Phosphoramidite Precursor; ACE-TBDMS Uridine Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and purity suitable for sensitive pharmaceutical synthesis. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development and cGMP manufacturing needs with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.