Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(2-amino-4,5-dihydro-4-oxo-1H-pyrrolo3,2-dpyrimidin-7-yl)tetrahydro-6-(hydroxymethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a high-purity, complex heterocyclic building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate for the creation of novel nucleoside analogs and other biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of antiviral agents, anticancer therapeutics, and other innovative drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analog drugs targeting viral infections and cancer.
• Antiviral Drug Development: Used in research programs focused on creating new therapeutic agents against a range of viral pathogens.
• Oncology Research: Serves as a building block for potential chemotherapeutic compounds and targeted cancer therapies.
• Biochemical Research: Employed in academic and industrial labs for studying enzyme interactions and nucleotide metabolism.
• Process Chemistry & Scale-up: Used in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis for clients.

Basic Information

Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(2-amino-4,5-dihydro-4-oxo-1H-pyrrolo3,2-dpyrimidin-7-yl)tetrahydro-6-(hydroxymethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	284490-16-0
Molecular Formula	C21H28N4O7
Molecular Weight	448.47 g/mol
Synonyms	tert-Butyl (3aS,4S,6R,6aR)-4-(2-amino-4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; (3aS,4S,6R,6aR)-tert-Butyl 4-(2-amino-4-oxo-1,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; 284490-16-0; Advanced Nucleoside Intermediate; Pyrrolopyrimidine Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for research and pharmaceutical development. Certificates of Analysis (COA) are provided with each batch, detailing purity and confirming identity through methods such as HPLC, NMR, and mass spectrometry. We ensure compliance with relevant internal specifications and support our clients' needs for regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.