Description

2-[[(3aR,4S,6R,6aS)-6-[7-Amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-acetic acid methyl ester is a sophisticated nucleoside analog intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases and cellular enzymes. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of next-generation nucleotide-based drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside analog prodrugs for antiviral applications.
• Antiviral Drug Research: Serves as a key scaffold for developing therapeutics against viruses such as hepatitis and herpes.
• Oncology Research: Used in the discovery and development of nucleotide-based chemotherapeutic agents targeting cancer cell proliferation.
• Biochemical Tool Compound: Employed in enzymatic studies to investigate the mechanisms of polymerase inhibition.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized compounds for client projects.

Basic Information

Product Name	2-[[(3aR,4S,6R,6aS)-6-[7-Amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-acetic acid methyl ester
CAS No.	274693-23-1
Molecular Formula	C18H26N6O5S
Molecular Weight	438.50 g/mol
Synonyms	Methyl 2-(((3aR,4S,6R,6aS)-6-(7-amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydrocyclopenta[d][1,3]dioxol-4-yl)oxy)acetate; 7-Amino-5-(propylthio)-3-((3aR,4S,6R,6aS)-4-((2-methoxy-2-oxoethoxy)methyl)-2,2-dimethyltetrahydrocyclopenta[d][1,3]dioxol-6-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; Nucleoside triazole intermediate; Propylthio-triazolopyrimidine nucleoside ester.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for research and development purposes. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.