Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(6-chloro-9H-purin-9-yl)methyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a sophisticated nucleoside analog building block, a key intermediate in the synthesis of modified oligonucleotides and therapeutic agents. Its complex structure, featuring a protected carboxylic acid and a silyl ether group, provides precise control over chemical reactivity for advanced pharmaceutical research and development. This high-purity intermediate is essential for medicinal chemists and process development scientists working on antiviral, anticancer, and other targeted therapeutic programs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside-based active pharmaceutical ingredients (APIs) and prodrugs.
• Antiviral Drug Development: Used in research and process chemistry for creating potential therapeutics targeting viral polymerases.
• Anticancer Agent Synthesis: Serves as a precursor in the development of nucleotide analogs designed to inhibit cancer cell proliferation.
• Oligonucleotide Chemistry: Employed in the solid-phase or solution-phase synthesis of modified oligonucleotides for antisense, siRNA, or aptamer applications.
• Process Chemistry & Scale-Up: Provides a defined, high-quality starting point for optimizing synthetic routes from laboratory to pilot and commercial scale.
• Biochemical Research: Used as a tool compound to study enzyme mechanisms, particularly those involving nucleotide-binding proteins and polymerases.

Basic Information

Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(6-chloro-9H-purin-9-yl)methyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	258834-91-2
Molecular Formula	C24H34ClN5O5Si
Molecular Weight	544.10 g/mol
Synonyms	9-[(4-Carboxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-6-yl)methyl]-6-chloro-9H-purine, tert-butyl ester, 6-O-(tert-butyldimethylsilyl) derivative; (3aS,4S,6R,6aR)-6-[[(1,1-Dimethylethyl)dimethylsilyl]oxymethyl]-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole-4-carboxylic acid, 4-[(6-chloro-9H-purin-9-yl)methyl]-, 1,1-dimethylethyl ester; 6-Chloro-9-[(4-(tert-butoxycarbonyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl)methyl]purine, 6-O-TBDMS protected; tert-Butyl (3aS,4S,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carboxylate, 4-((6-chloropurin-9-yl)methyl) derivative; Nucleoside intermediate 258834-91-2
EINECS	Contact for details

Quality Control

This high-value pharmaceutical intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and mass spectrometry. Our quality protocols are designed to support GMP-for-intermediate standards for traceability and documentation, ensuring reliability for critical research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.