Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-6-(hydroxymethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), offering a protected functional group scaffold for precise molecular construction. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring sophisticated chiral chemistry.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of proprietary drug candidates and complex APIs.
• Chiral Synthesis: Serves as a stereochemically pure precursor for constructing molecules with specific three-dimensional configurations essential for biological activity.
• Process Chemistry Development: Used in route scouting and optimization for scalable GMP manufacturing of target molecules.
• Medicinal Chemistry Research: Enables the exploration of new chemical entities (NCEs) in academic and industrial R&D laboratories.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds for clients.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) and tert-butyl ester groups provide orthogonal protection for sensitive functionalities during synthetic sequences.

Basic Information

Item	Details
Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-6-(hydroxymethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)-
CAS No.	258834-89-8
Molecular Formula	C20H35NO6Si
Molecular Weight	413.59 g/mol
Synonyms	(3aR,4R,6S,6aS)-6-(Hydroxymethyl)-2,2-dimethyltetrahydro-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5H-1,3-dioxolo[4,5-c]pyrrole-5-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl (3aR,4R,6S,6aS)-6-(hydroxymethyl)-2,2-dimethyl-4-((tert-butyldimethylsilyloxy)methyl)tetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; TBDMS-protected pyrrolidine derivative; Advanced chiral pyrrolidine intermediate; Protected amino acid derivative.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing specific results for chiral purity, assay, and impurity profiles are available upon request. Our quality system supports development under GMP guidelines for investigational products.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.