Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a sophisticated, high-purity nucleoside analog intermediate designed for advanced pharmaceutical synthesis. This compound is critical for the research and development of novel antiviral and anticancer therapeutics, offering a key building block with precise stereochemistry. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex nucleoside-based antiviral drugs.
• Anticancer Drug Research: Serves as a critical scaffold for developing novel chemotherapeutic agents targeting specific cellular pathways.
• Protease Inhibitor Development: Used in the research and production of protease inhibitors for treating viral infections.
• Biochemical Research: Employed in academic and industrial laboratories for studying enzyme mechanisms and nucleotide metabolism.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing custom synthesis for client-specific molecular targets.
• Process Chemistry: Utilized in scaling up synthetic routes from laboratory to pilot and commercial manufacturing scales.

Basic Information

Item	Detail
Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	222631-47-2
Molecular Formula	C27H41N5O6Si
Molecular Weight	559.74 g/mol
Synonyms	tert-Butyl (3aS,4S,6R,6aR)-4-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-5-carboxylate; 5'-O-(tert-Butyldimethylsilyl)-2',3'-O-isopropylideneadenosine Derivative; TBS-Protected Isopropylidene Adenosine Intermediate; Nucleoside Analog Intermediate 222631-47-2; Adenosine Derivative, TBS and Acetonide Protected; (3aS,4S,6R,6aR)-Isomer of Protected Nucleoside
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3aS,4S,6R,6aR)-Isomer
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.