Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(2-amino-4,5-dihydro-4-oxo-1H-pyrrolo3,2-dpyrimidin-7-yl)tetrahydro-2,2,6-trimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a sophisticated, high-purity chemical intermediate characterized by its complex heterocyclic structure. This compound is of critical importance in modern pharmaceutical synthesis, serving as a key building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the discovery and production of advanced therapeutic agents, particularly in oncology and antiviral drug development.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Oncology Research: Used as a building block for novel nucleoside analogs and other compounds targeting cancer pathways.
• Antiviral Drug Development: Serves as a key synthon in the research and production of antiviral medications.
• Process Chemistry & Scale-up: Employed in process research and development (PR&D) and pilot-scale manufacturing for route optimization.
• Contract Manufacturing (CMO/CDMO): Supplied to contract manufacturing organizations for cGMP production of clinical trial materials and commercial APIs.
• Academic & Industrial R&D: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(2-amino-4,5-dihydro-4-oxo-1H-pyrrolo3,2-dpyrimidin-7-yl)tetrahydro-2,2,6-trimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	222631-43-8
Molecular Formula	C20H26N4O6
Molecular Weight	418.45 g/mol
Synonyms	(3aS,4S,6R,6aR)-4-(2-Amino-4,5-dihydro-4-oxo-1H-pyrrolo[3,2-d]pyrimidin-7-yl)tetrahydro-2,2,6-trimethyl-5H-1,3-dioxolo[4,5-c]pyrrole-5-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl (3aS,4S,6R,6aR)-4-(2-amino-4,5-dihydro-4-oxo-1H-pyrrolo[3,2-d]pyrimidin-7-yl)tetrahydro-2,2,6-trimethyl-5H-1,3-dioxolo[4,5-c]pyrrole-5-carboxylate; CAS 222631-43-8; Advanced Pharmaceutical Intermediate; Nucleoside Analog Precursor; Pyrrolopyrimidine Derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. The material is manufactured and controlled under a quality system aligned with ICH Q7 guidelines. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, and regulatory support documentation (including DMF/EDMF readiness) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.