Description

rac-2,2'-(((3aR,3a'R,4R,4'R,6S,6aS,6'S,6a'S)-((5-nitro-2-(propylthio)pyrimidine-4,6-diyl)bis(azanediyl))bis(2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxole-6,4-diyl))bis(oxy))bis(ethan-1-ol) CAS NO 1882095-50-2 is a sophisticated, high-purity chiral intermediate characterized by its complex bicyclic acetal-protected diol structure linked to a nitro-substituted pyrimidine core. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel nucleoside analogs and other bioactive molecules. It is primarily sought after by contract research organizations (CROs), pharmaceutical companies, and advanced academic laboratories engaged in antiviral, anticancer, or other targeted therapeutic programs.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel nucleoside and nucleotide analogs with potential therapeutic activity.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Serves as a precursor in the creation of chemotherapeutic agents designed to interfere with DNA/RNA synthesis in cancer cells.
• Protease Inhibitor Development: The structural complexity makes it suitable for constructing key fragments in protease inhibitor candidates.
• Chemical Biology & Probe Development: Utilized in creating molecular probes to study enzyme mechanisms and cellular pathways.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of advanced drug candidates.

Basic Information

Product Name	rac-2,2'-(((3aR,3a'R,4R,4'R,6S,6aS,6'S,6a'S)-((5-nitro-2-(propylthio)pyrimidine-4,6-diyl)bis(azanediyl))bis(2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxole-6,4-diyl))bis(oxy))bis(ethan-1-ol)
CAS No.	1882095-50-2
Molecular Formula	C32H44N6O10S
Molecular Weight	704.79 g/mol
Synonyms	1,3-Dideoxy-1,3-bis[[(1S,2R,3S,4R)-2,3-O-(1-methylethylidene)-4-(2-hydroxyethoxy)-1,2,3,4-cyclopentanetetrayl]amino]-5-nitro-6-(propylthio)pyrimidine; rac-Isomer of the Protected Diol-Nitro Pyrimidine Intermediate; 5-Nitro-2-(propylthio)pyrimidine-4,6-diamine Derivative; Bicyclic Acetal-Protected Nucleoside Analog Intermediate; (rac)-2,2'-((((3aR,3a'R,4R,4'R,6S,6aS,6'S,6a'S)-((5-Nitro-2-(propylthio)pyrimidine-4,6-diyl)bis(azanediyl))bis(2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxole-6,4-diyl))bis(oxy))bis(ethanol)
EINECS	Contact for details

Quality Control

Our rac-2,2'-(((3aR,3a'R,4R,4'R,6S,6aS,6'S,6a'S)-((5-nitro-2-(propylthio)pyrimidine-4,6-diyl)bis(azanediyl))bis(2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxole-6,4-diyl))bis(oxy))bis(ethan-1-ol) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound may be sensitive to moisture and should be handled under inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Reported value

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.