Description

Acetic acid, 2-[[(1S,2S,3S,4R)-4-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-2,3-dihydroxycyclopentyl]oxy]-, ethyl ester is a high-purity, complex heterocyclic compound designed for advanced pharmaceutical research and development. This molecule serves as a critical intermediate or reference standard in the synthesis of novel therapeutic agents, particularly targeting kinase inhibition and other enzymatic pathways. It is essential for medicinal chemistry programs within global pharmaceutical and biotechnology companies focused on developing next-generation treatments for oncology, inflammatory, and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of targeted small-molecule drug candidates.
• Kinase Inhibitor Research: Used in the development and screening of compounds designed to modulate specific kinase activity.
• Reference Standard: Serves as an analytical standard for quality control and method development in API (Active Pharmaceutical Ingredient) manufacturing.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Biochemical Assays: Utilized as a tool compound in enzymatic and cellular assays to study biological pathways.
• Preclinical Development: Supports early-stage drug discovery from hit-to-lead and lead optimization phases.

Basic Information

Product Name	Acetic acid, 2-[[(1S,2S,3S,4R)-4-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-2,3-dihydroxycyclopentyl]oxy]-, ethyl ester
CAS No.	1402150-10-0
Molecular Formula	C29H32F2N6O5S
Molecular Weight	614.66 g/mol
Synonyms	Ethyl 2-(((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)acetate; UNII-9V6S8A6R6B; 9V6S8A6R6B; CS-1777; AZD-9291 metabolite; Osimertinib metabolite; AZD9291 metabolite
EINECS	Contact for details

Quality Control

Every batch of this advanced pharmaceutical intermediate is produced under strict quality management systems and undergoes comprehensive analytical characterization. Our rigorous quality testing ensures identity, purity, and consistency, supporting compliance with ICH guidelines for impurities. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The material is hygroscopic and should be handled in a dry environment to prevent moisture uptake. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.