Description

4,5-PyriMidinediaMine, 6-chloro-N4-[(3aS,4R,6S,6aR)-6-[2-[[(1,1-diMethylethyl)diMethylsilyl]oxy]ethoxy]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]-2-(propylthio)- is a sophisticated nucleoside analog intermediate of significant importance in modern pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases and cellular replication pathways. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of nucleoside-based antiviral drugs.
• Antiviral Drug Development: Research and production of compounds targeting hepatitis, HIV, and other viral infections.
• Oncology Research: Building block for developing nucleoside analogs with potential anticancer activity.
• Pro-drug Synthesis: Used in creating masked or modified versions of active nucleosides to improve pharmacokinetics.
• Biochemical Research: Tool compound for studying enzyme mechanisms, particularly those involving polymerases and kinases.
• Fine Chemical Synthesis: Intermediate for custom synthesis and contract manufacturing of specialized organic molecules.

Basic Information

Product Name	4,5-PyriMidinediaMine, 6-chloro-N4-[(3aS,4R,6S,6aR)-6-[2-[[(1,1-diMethylethyl)diMethylsilyl]oxy]ethoxy]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]-2-(propylthio)-
CAS No.	1400665-91-9
Molecular Formula	C24H40ClN3O4SSi
Molecular Weight	530.18 g/mol
Synonyms	6-Chloro-2-(propylthio)-9-[(1'R,2'R,3'S,4'R)-2',3'-O-isopropylidene-4'-[[2-[(tert-butyldimethylsilyl)oxy]ethoxy]methyl]cyclopentyl]purine; TBDMS-protected nucleoside intermediate; 6-Chloro-2-propylthio-9-(protected cyclopentyl)purine; Antiviral nucleoside precursor; CAS 1400665-91-9; Protected 6-chloropurine derivative; Cyclopentyl nucleoside analog intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for pharmaceutical research. All materials are characterized by modern analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Keep away from fluoride sources and strong alkali.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.